Mechanism of Neuroinflammation in Traumatic Brain Injury

  • Sicheng Zhu Zhejiang Normal University college of Physical Education and Health Sciences
  • Yanzhen Wu Zhejiang Normal University college of Physical Education and Health Sciences
  • Qimei Lin Zhejiang Normal University college of Physical Education and Health Sciences
  • Zhe Yang Zhejiang Normal University college of Physical Education and Health Sciences
  • Yinan Chen Zhejiang Normal University college of Physical Education and Health Sciences
  • Jiyun Guo Zhejiang Normal University college of Physical Education and Health Sciences
Ariticle ID: 2130
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Keywords: TBI, Neuroinflammation, Cytokines, Blood-brain barrier

Abstract

To understand the interaction between inflammatory factors,blood-brain barrier and immune cells after traumatic brain injury(TBI).We review the recent literatures about inflammation post TBI.Microglia,astrocyte as well as inflammatory cytokines in inflammation are mentioned.In addition,interaction between immune cells through cytokines are mainly elaborated,in order to provide reference for treatment towards to TBI and other symptoms caused by acute brain injury.

References

[1] Capizzi,A.,J(2020). Woo,and M.Verduzco-Gutierrez,Traumatic Brain Injury:An Overview of Epidemiology,Pathophysiology,and Medical Management.Med Clin North Am,104(2):p.213-238.

[2] Wilson,L(2017),et al.,The chronic and evolving neurological consequences of traumatic brain injury.Lancet Neurol,16(10):p.813-825.

[3] Obermeier,B(2016),A.Verma,and R.M.Ransohoff,The blood-brain barrier.Handb Clin Neurol,133:p.39-59.

[4] Hay,J.R(2015).,et al.,Blood-Brain Barrier Disruption Is an Early Event That May Persist for Many Years After Traumatic Brain Injury in Humans.J Neuropathol Exp Neurol,74(12):p.1147-57.

[5] Sivandzade,F(2020).,F.Alqahtani,and L.Cucullo,Traumatic Brain Injury and Blood-Brain Barrier(BBB):Underlying Pathophysiological Mechanisms and the Influence of Cigarette Smoking as a Premorbid Condition.Int J Mol Sci,21(8).

[6] Plesnila,N.(2016),The immune system in traumatic brain injury.Curr Opin Pharmacol,26:p.110-7.

[7] Atangana,E(2017),et al.,Intravascular Inflammation Triggers Intracerebral Activated Microglia and Contributes to Secondary Brain Injury After Experimental Subarachnoid Hemorrhage(eSAH).Transl Stroke Res,8(2):p.144-156.

[8] Nishioku,T(2009),et al.,Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brain barrier caused by

lipopolysaccharide-induced sepsis in mice.Cell Mol Neurobiol,29(3):p.309-16.

[9] Xiong,X.Y.,L.Liu,and Q.W.Yang(2016),Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke.Prog Neurobiol,142:p.23-44.

[10] Gomez-Nicola,D.and V.H.Perry(2015),Microglial dynamics and role in the healthy and diseased brain:a paradigm of functional plasticity.Neuroscientist,21(2):p.169-84.

[11] Sofroniew,M.V.and H.V.Vinters(2010),Astrocytes:biology and pathology.Acta Neuropathol,119(1):p.7-35.

[12] Watanabe,M.,et al(2016),Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation.Sci Rep,6:p.38387.

[13] Clark,I.A.,L.M.Alleva,and B.Vissel(2010),The roles of TNF in brain dysfunction and disease.Pharmacol Ther,128(3):p.519-48.

[14] von Bernhardi,R.,et al.,Role of TGFbeta signaling in the pathogenesis of Alzheimer’s disease.Front Cell Neurosci,2015.9:p.426.

[15] Dinarello,C.A(2018),Introduction to the interleukin-1 family of cytokines and receptors:Drivers of innate inflammation and acquired immunity.Immunol Rev,2018.281(1):p.5-7.

[16] Shaik-Dasthagirisaheb,Y.B.and P.Conti,The Role of Mast Cells in Alzheimer’s Disease.Adv Clin Exp Med,25(4):p.781-7.

[17] Taracanova,A.,et al(2018),Substance P and IL-33 administered together stimulate a marked secretion of IL-1beta from human mast cells,inhibited by methoxyluteolin.Proc Natl Acad Sci U S A,115(40):p.E9381-E9390.

[18] Murray,P.J.and T.A.Wynn(2011).Obstacles and opportunities for understanding macrophage polarization.J Leukoc Biol,89(4):p.557-63.

[19] Varvara,G(2018),et al.,Stimulated mast cells release inflammatory cytokines:potential suppression and therapeutical aspects.J Biol Regul Homeost Agents,32(6):p.1355-1360.

Published
2021-07-19