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The Targets Prediction of ZYJSW on LDH by Network Pharmacology

Xinzhi Li, Qiang Zhang, Yongan Wei, Chang Tan, Shigang Li

Abstract


This is a network pharmacology about Zhuangyaojianshenwan(ZYJSW) treats Lumbar disc herniation (LDH),we will
talk about the mechanisms.We used oral bioavailability and drug-likeness filtration to find the active ingredients of ZYJSW.At the
same time,we sought out the targets.Gene Cards and OMIM were used to find the targets of LDH.So Venn diagram was easy to be
drawn out.We used the genetic intersection between the drug and the disease to structure a PPI network,at the same time,bar plot
was shown.At last,KEGG pathway analysis and Gene Ontology enrichment analysis were conducted. We could see the top three
pathways from the analysis, they were AGE-RAGE signaling pathway in diabetic complications,Lipid and atherosclerosis and
Kaposi sarcoma-associated herpesvirus infection.This study uses network pharmacology and provides a strategy that can help us
to explore the mechanisms by which ZYJSW treats LDH.

Keywords


Active ingredients; Lumbar disc herniation; Network pharmacology; Zhuangyaojianshenwan

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References


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DOI: http://dx.doi.org/10.18282/l-e.v10i6.2787

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