The Targets Prediction of ZYJSW on LDH by Network Pharmacology
Abstract
This is a network pharmacology about Zhuangyaojianshenwan(ZYJSW) treats Lumbar disc herniation (LDH),we will talk about the mechanisms.We used oral bioavailability and drug-likeness filtration to find the active ingredients of ZYJSW.At the same time,we sought out the targets.Gene Cards and OMIM were used to find the targets of LDH.So Venn diagram was easy to be drawn out.We used the genetic intersection between the drug and the disease to structure a PPI network,at the same time,bar plot was shown.At last,KEGG pathway analysis and Gene Ontology enrichment analysis were conducted. We could see the top three pathways from the analysis, they were AGE-RAGE signaling pathway in diabetic complications,Lipid and atherosclerosis and Kaposi sarcoma-associated herpesvirus infection.This study uses network pharmacology and provides a strategy that can help us to explore the mechanisms by which ZYJSW treats LDH.References
["[1] Dai F, Dai YX, Jiang H, Yu PF, Liu JT. Non-surgical treatment with XSHHD for ruptured lumbar disc herniation: a 3-year prospective observational study. BMC Musculoskelet Disord. 2020 Oct 19;21(1):690. doi: 10.1186/s12891-020-03723-2.PMID:33076896;PMCID: PMC7574183.","[2] Xu J, Ding X, Wu J, Zhou X, Jin K, Yan M, Ma J, Wu X, Ye J, Mo W. A randomized controlled study for the treatment of middle-aged and old-aged lumbar disc herniation by Shis spine balance manipulation combined with bone and muscle guidance. Medicine (Baltimore). 2020 Dec 18;99(51):e23812. doi: 10.1097/MD.0000000000023812. PMID: 33371159; PMCID: PMC7748321.","[3] Keles BY, Yalcinkaya EY, Gunduz B, Bardak AN, Erhan B. Kinesio Taping in patients with lumbar disc herniation: A randomised, controlled, double-blind study. J Back Musculoskelet Rehabil. 2017;30(3):543-550. doi: 10.3233/BMR-150491. PMID: 27858685.","[4] Ezeldin M, Leonardi M, Princiotta C, Dallu2019olio M, Tharwat M, Zaki M, Abdel-Wanis ME, Cirillo L. Percutaneous ozone nucleolysis for lumbar disc herniation. Neuroradiology. 2018 Nov;60(11):1231-1241. doi: 10.1007/s00234-018-2083-4. Epub 2018 Sep 11. Erratum in: Neuroradiology. 2019 Jul 11;: PMID: 30206674; PMCID: PMC6208962.","[5] Luo Huawen. The effect of Zhuangyao Jianshen Pill combined with Liuwei Dihuang Pill in the treatment of intractable low back pain due to strain [J]. Chinese Contemporary Medicine, 2018, 25(06): 93-95.","[6] Tao Xianghui, Xue Lixia, Liu Chun. Clinical observation of Zhuangyao Jianshen pill combined with acupuncture in the treatment of low back pain due to strain and its effect on the content of ","Th_1 and Th_2 cells in peripheral blood [J]. Chinese Folk Therapy, 2020, 28(14) :54-56.","[7] Song Xiaoping. Analysis of the efficacy of drugs combined with fire therapy and electroacupuncture in the treatment of 96 cases of lumbar disc herniation [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2018, 41(05): 83-85.","[8] Wang Xiuqin, Lu Weisheng, Lin Tong. Study on the quality standard of Zhuangyao Jianshen Pills [J]. New Chinese Medicines and Clinical Pharmacology, 2016, 27(06):855-859.","[9] Fang T, Liu L, Liu W. Network pharmacology-based strategy for predicting therapy targets of Tripterygium wilfordii on acute myeloid leukemia. Medicine (Baltimore). 2020 Dec 11;99(50):e23546. doi: 10.1097/MD.0000000000023546. PMID: 33327305; PMCID: PMC7738111.","[10] Zhang X, Shen T, Zhou X, Tang X, Gao R, Xu L, Wang L, Zhou Z, Lin J, Hu Y. Network pharmacology based virtual screening of active constituents of Prunella vulgaris L. and the molecular mechanism against breast cancer. Sci Rep. 2020 Sep 25;10(1):15730. doi: 10.1038/s41598-020-72797-8. PMID: 32978480; PMCID: PMC7519149.","[11] Niu WH, Wu F, Cao WY, Wu ZG, Chao YC, Liang C. Network pharmacology for the identification of phytochemicals in traditional Chinese medicine for COVID-19 that may regulate interleukin-6. Biosci Rep. 2021 Jan 29;41(1):BSR20202583. doi: 10.1042/BSR20202583. Erratum in: Biosci Rep. 2021 Feb 26;41(2): PMID: 33146673; PMCID: PMC7809559.","[12] Liu C, Yin Z, Feng T, Zhang M, Zhou Z, Zhou Y. An integrated network pharmacology and RNA-Seq approach for exploring the preventive effect of Lonicerae japonicae flos on LPS-induced acute lung injury. J Ethnopharmacol. 2021 Jan 10;264:113364. doi: 10.1016/j.jep.2020.113364. Epub 2020 Sep 9. PMID: 32916233; PMCID: PMC7480403.","[13] Deng Y, Li Q, Li M, Han T, Li G, Liu Q. Network Pharmacology Identifies the Mechanisms of Sang-Xing-Zhi-Ke-Fang against Pharyngitis. Evid Based Complement Alternat Med. 2020 Oct 12;2020:2421916. doi: 10.1155/2020/2421916. PMID: 33101439; PMCID: PMC7576344.","[14] Wang M, Wang Q, Du Y, Zhang X. Network Pharmacology-Based Strategy to Investigate Pharmacological Mechanisms of Qiaoshao Formula for Treatment of Premature Ejaculation. Evid Based Complement Alternat Med. 2020 Nov 11;2020:1418634. doi: 10.1155/2020/1418634. PMID: 33273947; PMCID: PMC7676949.","[15] Zhang D, Dong Y, Lv J, Zhang B, Zhang X, Lin Z. Network pharmacology modeling identifies synergistic interaction of therapeutic and toxicological mechanisms for Tripterygium hypoglaucum Hutch. BMC Complement Med Ther. 2021 Jan 15;21(1):38. doi: 10.1186/s12906-021-03210-8. PMID: 33446184; PMCID: PMC7809745."]
Authors contributing to this journal agree to publish their articles under the Creative Commons Attribution-Noncommercial 4.0 International License, allowing third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit, that the work is not used for commercial purposes, and that in the event of reuse or distribution, the terms of this license are made clear. With this license, the authors hold the copyright without restrictions and are allowed to retain publishing rights without restrictions as long as this journal is the original publisher of the articles.
