Effects of Exercise on Hippocampus-entorhinal Cortex and EpilePsy After TBI

Yongzhi Li; Xiuting Lin; Lijia Zhao; Le Guo; Lixin Yu; Sicheng Zhu

doi:10.18282/l-e.v9i5.2076

Yongzhi Li College of Physical Education and health Sciences, Zhejiang Normal University
Xiuting Lin College of Physical Education and health Sciences, Zhejiang Normal University
Lijia Zhao College of Physical Education and health Sciences, Zhejiang Normal University
Le Guo College of Physical Education and health Sciences, Zhejiang Normal University
Lixin Yu College of Physical Education and health Sciences, Zhejiang Normal University
Sicheng Zhu College of Physical Education and health Sciences, Zhejiang Normal University

Article ID: 2076

50 Views, 11 PDF Downloads

DOI: https://doi.org/10.18282/l-e.v9i5.2076

Keywords: TBI, Epilepsy, Exercise

Abstract

Traumatic brain injury can lead to a series of cognitive deficits and dyskinesias, including hippocampal memory dysfunction and dyskinesia of the contralateral limb. Theta oscillation has been recognized to be involved in the memory storage and processing functions of people. Epilepsy is a neurological disorder characterized by frequent seizures and is believed to originate from abnormal electrical activity in the brain. Studies have found that moderate exercise has a protective effect on the brain and can promote recovery after brain injury. The protective effects of exercise include reducing the frequency of epileptic seizures and reducing the behavioral disorders of animals after brain injury. Exercise is related to the decrease of EEG epileptiform discharge and the increase of seizure threshold. In the study of epilepsy and epilepsy animal models, it is found that aerobic exercise training can delay the occurrence of epilepsy, reduce the frequency of seizures, and promote good plastic changes in the hippocampus. Therefore, this review focuses on the effects of exercise on the hippocampus-entorhinal cortex and seizures after brain injury, and provides a new perspective to clarify the neuroprotective effects of exercise.

References

[1] Buchele,F.,M.M.Morawska,S.R.Schreglmann,et al(2016).Novel Rat Model of Weight Drop-Induced Closed Diffuse Traumatic Brain Injury Compatible with Electrophysiological Recordings of Vigilance States.Neurotrauma33(13) 1171-1180.

[2] Verley,D.R.,D.Torolira,B.Pulido,et al(2018).Remote Changes in Cortical Excitability after Experimental Traumatic Brain Injury and Functional Reorganization.Neurotrauma35(20): 2448-2461.

[3] Capovilla,G.,K.R.Kaufman,E.Perucca,S.L.Moshe and R.M Arida(2016).Epilepsy,seizures,physical exercise,and sports:A report from the ILAE Task Force on Sports and Epilepsy.Epilepsia,57(1):6-12.

[4] Pimentel,J.,R.Tojal and J(2015).Morgado Epilepsy and physical exercise.Seizure,25:87-94.

[5] Schmitt,S.and M.A Dichter(2015).Electrophysiologic recordings in traumatic brain injury.Handb Clin Neurol,127:319-339.

[6] Lewine,J.D.,S.Plis,A.Ulloa,et al(2019).Quantitative EEG Biomarkers for Mild Traumatic Brain Injury.Clin Neurophysiol,36(4):298-305.

[7] Lee,D.J.,G.G.Gurkoff,A.Izadi,et al.Septohippocampal Neuromodulation Improves Cognition after Traumatic Brain Injury.[J].Journal of Neu rotrauma,2015,32(22):1822-1832.

[8] Bick,S.K.and E.N(2016).Eskandar Neuromodulation for restoring memory.Neurosurg Focus,40(5):E5.

[9] Ouyang,W.,Q.Yan,Y.Zhang and Z.Fan(2017).Moderate injury in motor-sensory cortex causes behavioral deficits accompanied by electrophysiological changes in mice adulthood.PLoS One,12(2):e0171976.

[10] Trimper,J.B.,C.R.Galloway,A.C.Jones,K.Mandi and J.R.Manns(2017).Gamma Oscillations in Rat Hippocampal Subregions Dentate Gyrus,CA3,CA1,and Subiculum Underlie Associative Memory Encoding.Cell Reports,21(9):2419-2432.

[11] Ono,T.and T.Nakashima(2018).[Exercise and brain function.].Clin Calcium,28(1): 57-64.

[12] Svensson,M.,J.Lexell and T.Deierborg(2015).Effects of Physical Exercise on Neuroinflammation,Neuroplasticity,Neurodegeneration,and Behavior:What We Can Learn From Animal Models in Clinical Settings.Neurorehabil Neural Repair,29(6):577-589.

[13] Zafonte,R.D.,S.L.Shih,M.A.Iaccarino and C.O.Tan(2018).Neurologic benefits of sports and exercise.Handb Clin Neurol,158:463-471.

[14] Nakken,K.O(2000).[Should people with epilepsy exercise?]Tidsskr Nor Laegeforen,120(25): 3051-3053.

[15] Carrizosa-Moog,J.,L.D.Ladino,V.Benjumea-Cuartas,et al(2018).Epilepsy,Physical Activity and Sports:A Narrative Review.Can J Neurol Sci,45(6): 624-632.

[16] Fogelman,D.and R.Zafonte(2012).Exercise to enhance neurocognitive function after traumatic brain injury.PM R,4(11):908-913.

[17] Wang,X.,M.Zhang,R.Feng,et al(2014).Physical exercise training and neurovascular unit in ischemic stroke.Neuroscience,271:99-107.

[18] Patki,G.,L.Li,F.Allam,et al(2014).Moderate treadmill exercise rescues anxiety and depression-like behavior as well as memory impairment in a rat model of posttraumatic stress disorder.Physiol Behav,130: 47-53.

[19] Griesbach,G.S.,D.A.Hovda,R.Molteni,A.Wu and F.Gomez-Pinilla(2004).Voluntary exercise following traumatic brain injury:brain-derived neurotrophic factor upregulation and recovery offunction.Neuroscience,125(1): 129-139.

[20] Jones,T.A.,C.J.Chu,L.A.Grande and A.D.Gregory(1999).Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats.Neurosci,19(22): 10153-10163.