EBV-positive LMP1-mediated Signal Pathway in Nasopharyngeal Carcinoma

Xiaohui Li, Ji Yin, Sen Li, Wenjian Hu


Nasopharyngeal carcinoma (NPC) is one of the main cancers and death factors of otorhinolaryngological malignant tumors. A number of studies have shown that the occurrence and development of NPC is clearly related to Epstein-Barr virus (EBV) infection. Among the few proteins expressed by EBV, latent membrane protein 1 (LMP1) is considered to be a protein with the function of oncogenes, because it can make the epithelium tend toward malignant transformation; therefore LMP1 plays an important role in the occurrence and development of NPC, and is also considered to be the oncogene of EBV. LMP1 can further affect cell migration and apoptosis by participating in multiple intracellular signal transduction pathways, which is closely related to a variety of lymphoid tissue diseases and malignant tumors; nasopharyngeal carcinoma is no exception. This article reviews the signal pathways mediated by LMP1 in NPC.


Epstein-Barr virus (EBV); Latent membrane protein 1 (LMP1); Nasopharyngeal Carcinoma (NPC); Signaling pathway

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DOI: https://doi.org/10.18282/l-e.v9i5.2015


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