Research Progress of Neural Stem Cell Transplantation Combined with Biological Scaffold in the Treatment of Spinal Cord Injury

Tao Li, Tanlong Wang


SCI is a kind of nerve injury disease caused by direct or indirect factors. The result is the damage of motor mechanism and the partial or total loss of sensory function below the injury site. The researchers found that planting neural stem cells in a biological scaffold and then colonizing the site of SCI greatly improved the survival rate of stem cells and promoted the repair of injury. However, different biomaterials have different differences. In order to better promote the recovery of function after SCI, it is important to select an appropriate scaffold combination.


Neural Stem Cell; Biological Scaffold; Spinal Cord Injury

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Biglari B, Child C, Yildirim TM, et al. Does surgical treatment within 4 hours after trauma have an influence on neurological remission in patients with acute spinal cord injury? [J]. Ther Clin Risk Manag, 2016, 12:1339-1346.

Sinescu C, Popa F, Grigorean VT, et al. Molecular basis of vascular events following spinal cord injury [J]. J Med Life, 2010, 3(3):254-261.

Han Y, Li X, Zhang Y, et al. Mesenchymal Stem Cells for Regenerative Medicine. Cells. 2019; 8(8):886.

Wan, R., Shi, X., Liu, JS., et al Research progress of mesenchymal stem cell secretory group in the treatment of spinal cord injury [R] China tissue engineering research, 2021,25 (07): 1088-1095.

Kadoya K, Lu P, Nguyen K, et al. Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration[J]. Nat Med, 2016, 22: 479-487.

Pereno V, Lei J, Carugo D, et al. Microstreaming inside model cells induced by ultrasound and microbubbles[J]. Langmuir, 2020, 36 (23): 6388-6398.

Vizoso FJ, Eiro N, Cid S, et al. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine. Int J Mol Sci. 2017; 18(9): pii: E1852.

Qian, NN., Zhang, Q., et al Mesenchymal stem cells for spinal cord injury: cell therapy and combination of new drugs and biomaterials [R] China tissue engineering research, 2021,25 (13).

Li Y, Liu Y, Xun X, et al. Three-Dimensional Porous Scaffolds with Biomimetic Microarchitecture and Bioactivity for Cartilage Tissue Engineering. ACS Appl Mater Interfaces. 2019; 11(40): 36359-36370.

Ji, HY, Gu, J., et al. Application of stem cells, tissue engineering scaffolds and neurotrophic factors in the treatment of spinal cord injury [R] China tissue engineering research, 2020,24 (25).

Carvalho MS, Silva JC, Udangawa RN, et al. Co-culture cell-derived extracellular matrix loaded electrospun microfibrous scaffolds for bone tissue engineering. Mater Sci Eng C.2019; 99: 479-490.

Rosenzweig ES, Brock JH, Lu P, et al. Restorative effects of human neural stem cell grafts on the primate spinal cord[J]. Nat Med,2018,24(4):484-490.

Marichal N, Reali C, Trujillo-Cenóz O, et al. Spinal cord stem cells in their microenvironment: the ependyma as a stem cell niche [J]. Adv Exp Med Biol, 2017, 1041: 55-79.

Yang, HN., Liu, L., Yu, CY., Wang, X., et al. Clinical research status and existing problems of neural stem cell transplantation in the treatment of spinal cord injury [R] Chinese Journal of spine and spinal cord, 2020,30 (09), 846-851.

Tian T., Li, XG., et al. Problems and challenges in regeneration and repair of spinal cord injury [R] China tissue engineering research, 2021, 25 (19): 3039-3048.

Zhao XM, He XY, Liu J, et al. Neural stem cell transplantation improves locomotor function in spinal cord transection rats associated with nerve regeneration and IGF-1 R expression[J]. Cell Transplant, 2019, 28(9-10): 1197-1211.

Zhang ZR., Wang FY., Wait Research Progress on cell repair of spinal cord injury [R] Chinese Journal of trauma, 2019, (12).

Yang Y, Pang M, Chen YY, et al. Human umbilical cord mesenchymal stem cells to treat spinal cord injury in the early chronic phase:study protocol for a prospective, multicenter, randomized, placebo-controlled, single-blinded clinical trial[J]. Neural Regen Res, 2020, 15(8): 1532-1538.

Wu PQ, Hong DC, et al. Research progress of hydrogel in animal experiment of spinal cord injury [R]. Biological orthopaedic materials and clinical research, 2020,17 (01).

Wang C., Yue, HB., Feng, Q., et al. Injectable Nanoreinforced Shape-Memory Hydrogel System for Regenerating Spinal Cord Tissue from Traumatic Injury [J]. ACS Appl Mater Interfaces, 2018, 10 (35): 29299-29307.

Michalski MH, Ross JS. The shape of things to come: 3D printing in medicine[J]. JAMA, 2014, 312(21): 2213-2214.

Cao, ZR., Zheng, B., Zhong, L., et al Collagen / heparin sulfate scaffold combined with neural stem cells promotes the recovery of motor function after spinal cord injury [R] China tissue engineering research, 2019,23 (34): 5454-5461.

Wang S, Guan S, Li W, et al. 3D culture of neural stem cells within conductive PEDOT layer-assembled chitosan/gelatin scaffolds for neural tissue engineering[J]. Mater Sci Eng C Mater Biol Appl,2018,93:890-901.

Qi GD, Jiang Q, et al Feasibility of co-culture of neural stem cells and spinal cord acellular scaffold in vitro [R] Chinese Rehabilitation Theory and practice, 2021,27 (01): 71-78.

Sugii S, Kida Y, Kawamura T, et al. Human and mouse adipose derived cells support feeder-independent induction of pluripotent stem cells [J]. Proc NatlAcad Sci U S A, 2010, 107(8): 3558-3563.

Zhou X, Shi G, Fan B,et al. Polycaprolactone electrospun fiber scaffold loaded with iPSCs- NSCs and ASCs as a novel tissue engineering scaffold for the treatment of spinal cord injury[J]. Int J Nanomedicine, 2018, 13(10):6265-6277.

DOI: https://doi.org/10.18282/rcsm.v4.i1.2916


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