Research Review on Effects of Exercise on Neuroglial Cells after Central Nervous System Diseases

  • Mengqi Ma Zhejiang Normal University
  • Yu Wu Zhejiang Normal University
Keywords: Astrocyte, Microglia, Exercise, Alzheimer's Disease, Parkinson's Disease

Abstract

Astrocyte and microglia are two types of neuroglia that are relatively widely distributed and functionally important in the mammalian central nervous system. These two cells play an important role in CNS diseases. The mechanism of the effect of exercise on various CNS diseases is still unclear. In this paper, the effect of exercise on neuroglial cells after CNS diseases is investigated in depth from the function and structure of glial cells.

References

Subhramanyam, CS., Wang, C., Hu, Q., et al. Microglia-mediated neuroinflammation in neurodegenerative diseases[J]. Semin Cell Dev Biol, 2019, 94: 112-120.

Liu, M., Jiang, L., Wen, M., et al. Microglia depletion exacerbates acute seizures and hippocampal neuronal degeneration in mouse models of epilepsy[J]. Am J Physiol Cell Physiol, 2020, 319(3): C605-C610.

Kriegstein, A. and A. Alvarez-Buylla.The glial nature of embryonic and adult neural stem cells[J].Annu Rev Neurosci, 2009, 32: 149-184.

Cunningham, C., A. Dunne, and A.B. Lopez-Rodriguez.Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity[J].Neuroscientist, 2019, 25(5): 455-474.

Biesmans, S., P.D. Acton, C. Cotto, et al.Effect of stress and peripheral immune activation on astrocyte activation in transgenic bioluminescent Gfap-luc mice[J].Glia, 2015, 63(7): 1126-1137.

Liddelow, S.A. and B.A. Barres.Reactive Astrocytes: Production, Function, and Therapeutic Potential[J].Immunity, 2017, 46(6): 957-967.

Liu, LR., Liu, J.C., Bao, J.S., et al.Interaction of Microglia and Astrocytes in the Neurovascular Unit[J].Front Immunol, 2020, 11: 1024.

Carter, SF., K. Herholz, P. Rosa-Neto, et al.Astrocyte Biomarkers in Alzheimer's Disease[J].Trends Mol Med, 2019, 25(2): 77-95.

Belaya, I., M. Ivanova, A. Sorvari, et al. Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease[J]. J Neuroinflammation, 2020, 17(1): 271.

Zhang, SS., Zhu, L., Peng, Y., et al. Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice[J]. J Neuroinflammation, 2022, 19(1): 34.

Real, CC., Suemoto, CK. Binda, KH., et al. Active lifestyle enhances protein expression profile in subjects with Lewy body pathology[J]. Dement Neuropsychol, 2021, 15(1): 41-50.

Real, CC., Garcia, PC., and Britto., L.R.G., Treadmill Exercise Prevents Increase of Neuroinflammation Markers Involved in the Dopaminergic Damage of the 6-OHDA Parkinson's Disease Model[J]. J Mol Neurosci, 2017, 63(1): 36-49.

Published
2022-07-14
Section
Original Research Article