Endoscopic Injection of Recombinant Human Adenovirus Type 5 Combined with Chemotherapy in the Treatment of Gastric Cancer: A Case Report

Guidong Jiang, Doudou Hu, Xiangjun Jiang


Purpose: To investigate the endoscopic injection of recombinant human adenovirus type 5 (H101) in the treatment of gastric cancer. Method: The diagnosis and treatment data of one patient with advanced gastric cancer were collected and discussed. Result: The patient ,a 51-year-old middle-aged male, was diagnosed with gastric malignant tumor (adenocarcinoma stage IV) with liver metastasis and lymph node metastasis combined with the results of gastroscopy, imaging and pathological examination. The patient underwent endoscopic injection of recombinant human adenovirus type 5 (H101) and chemotherapy.After 4 times of endoscopic treatment, the patient had no serious adverse reactions,pyloric obstruction was relieved, carcinoembryonic antigen was significantly reduced,intragastric ulcerated-like tumor was healed,the range of liver metastases was reduced.In outpatient follow-up, no tumor recurrence or metastasis was found, and the general condition was good. Conclusion: Endoscopic injection of recombinant human adenovirus type 5 showed good efficacy and safety and tolerability in patients with advanced gastric cancer.It is worthy of further promotion in clinical practice.


Gastric Cancer; Adenovirus; Chemotherapy; Case-Reporting

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DOI: https://doi.org/10.18282/rcsm.v4.i2.2904


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