Analysis of Risk Factors of Early-Onset Septicemia in Premature Infants

Ariticle ID: 2480

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Keywords: Premature Infants, Early-onset Septicemia, Mean Platelet Volume, Chorioamnionitis, GBS

Abstract

Objectives: To analyze the risk factors of early-onset septicemia in premature infants and to evaluate the significance of the risk factors in the early prognosis of premature infants. Methods: A total of 260 children with gestational age <34 weeks and birth weight <2000 grams diagnosed with early-onset septicemia admitted to the Neonatology Department of Dalian Municipal Woman and Children’s Medical Center (Group) (Chunliu Maternity Department) from July 2015 to July 2021 were retrospectively analyzed. According to the early prognosis, the patients were divided into poor prognosis group (severe sequelae, death during treatment) and cure group (improved or cured and discharged from hospital). The general clinical conditions of the two groups were compared, and the risk factors for poor prognosis of premature early-onset septicemia were analyzed. Results: 1. There were statistically significant differences in gestational age, birth weight, premature rupture of membranes (>12h), maternal chorioamnionitis or group B hemolytic streptococcus (GBS) infection, and incidence of NEC (Bell stage II or above) between the two groups (P<0.05). 2. Chorioamnionitis and/or GBS infection are independent risk factors for poor early prognosis of premature infants with early-onset septicemia. Conclusion: Maternal chorioamnionitis or GBS infection may be associated with a poor prognosis for early-onset septicemia in premature infants.