The Correlated of Serum Neutrophil Gelatinase Associated Lipid Transport Protein Levels and the Acute Coronary Syndrome
Abstract
Objectives: To study the serum neutrophil gelatinase associated lipid transport protein levels and coronary heart disease. Methods: 39 enrolled patients were divided into acute coronary syndrome (ACS) group (20 cases) and stable angina pectoris (control) group (19cases) according to the clinical manifestation and angiographic results. High-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), glutamic oxalacetic transaminase (AST), serum creatinine (Cr), Serum neutrophil gelatinase associated lipid transport protein (NGAL) were measured by Elisa test. And calculated the Genisi score of every patient. The association of NGAL with severity of coronary heart disease was studied. Results: that there were no significant differences in age, gender, BMI, smoking, hypertension, diabetes, ALT, TG, LDL-C and Cr between the control group and ACS group(P>0.05). The difference of Gensini score, NGAL, AST were statistically significant(P>0.01). The ordered Logistics regression analysis showed that the NGAL was an independent risk factor for coronary heart disease. Conclusion: NGAL may serve as an independent risk factor of CHD.
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