pisco_log
banner

Clinical Study of Compound Duzhong Jianggu Granules Combined with Glucosamine Sulfate in the Treatment of Knee Osteoarthritis

Pengfei Liu, Guojun Zhou, Zhenxing Qu, Zhibin Li

Abstract


Objective To investigate the clinical effects of a compound Du Zhong Jianggu granules combined with glucosamine sulfate capsules in the treatment of knee osteoarthritis. Methods A total of 104 patients with knee osteoarthritis who visited and were hospitalized in the hospital between January 2020 and March 2020 were selected and randomly divided into two groups of 52 patients: the control group patients received oral glucosamine sulfate capsules, 2 capsules / time, 3 times / D on a daily basis. Patients in the study group received compound Du Zhong Jianggu granules at 12 g / time for 3 times / D daily on the basis of oral glucosamine sulfate capsule therapy. After the two groups were consecutively treated for 6 weeks, the clinical outcomes of patients in the two groups were observed and compared, and the serological parameters including: Serum Hypersensitivity C-Reactive Protein (hs CRP), cyclooxygenase-2 (COX-2), cartilage oligomeric matrix protein(COMP) and matrix metalloproteinase-3 (MMP-3) were collected before and after treatment, respectively, and the above data were collected and compared. the above data were collected and subjected to comparative analysis. The visual analog scale (VAS) scores and Lysholm knee scores before and after treatment in the two groups were collected for comparative analysis. Results After 6 weeks of treatment, the therapeutic response rate of the control group was 80.77%, which was significantly lower than that of the study group (94.23%, P < 0.05). The levels of hs CRP, COX-2, comp, and MMP-3 were significantly lower in both groups, and the values of the same groups were significantly different before and after treatment (P < 0.05, P < 0.05), both of which were significantly lower than the control group (P < 0.05). After treatment, the VAS scores of both groups were significantly lower, but the Lysholm scores were significantly higher (P < 0.05). After completion of the 6-week treatment, the Lysholm scores of the study group were higher than those of the control group, and the VAS scores were significantly lower than those of the control group(P<0.05)。  Conclusion The compound Du Zhong Jianggu granules combined with glucosamine sulfate capsules can achieve good efficacy in the treatment of knee osteoarthritis, and this method has better clinical efficacy than glucosamine sulfate capsules alone.


Keywords


Compound Duzhong Jiangu Granules; Glucosamine Sulfate; Knee Osteoarthritis; Hs CRP; COX-2; COMP; MMP-3

Full Text:

PDF

References


Zhou K F, Xu J, Gu H J, et al. Clinical efficacy of glucosamine hydrochloride capsules in the treatment of patients with knee osteoarthritis and its effect on the levels of serum IL-1β beta and TNF-α [J]. Progress Mod Biomed, 2018, 18(9): 1694-1697.

Xu K, Kang B X, Sun S T, et al. Progress of TCM clinical research on knee osteoarthritis [J]. Acta Chinese Medicine, 2019, 34(10):2124-2129.

Joint Surgery Group, Orthopedic Society, Chinese Medical Association. Guideline for the Diagnosis and Treatment of Osteoarthritis (2018 edition) [J]. Chin J Orthop, 2018, 38(12): 705-715.

Jiang X Y, Wang D W. Evaluation criteria for clinical efficacy of orthopedics [M]. Beijing: People's Medical Publishing House, 2005: 123-124.

Yan G B. Visual anoalogue scale [J]. Chin J Joint Surg: Electronic Edition, 2014, 8(2): 34.

Heintjes E M, Bierma-Zeinstra S M, Berger M Y, et al. Lysholm scale and WOMAC index were responsive in prospective cohort of young general practice patients [J]. J Clin Epidemiol, 2008, 61(5): 481-488.

Sun Y H, Luo D F, Zhan Z J, Comparative study on the efficacy and safety of compound glucosamine hydrochloride capsules and tablets in the treatment of osteoarthritis [J]. Evaluation and analysis of drug use in Chinese hospitals, 2016, 16 (11): 1524-1526.

Gao B, Zou S M, Effect of glucosamine sulfate Capsule on knee osteoarthritis, China continuing Medical Education[J], 10(24):121-123.




DOI: http://dx.doi.org/10.18282/rcsm.v3.i2.2356

Refbacks

  • There are currently no refbacks.