pisco_log
banner

The Effects of Levodopa on Albinism

Yi Hao, Huina Ma, Siyuan Wang, Hairu Yan, Wei Zhou

Abstract


Albinism, a refractory disease with reduced pigmentation. And it has caused great distress to the patient's body and mind. How to treat the disease is a troubling problem in history. Levodopa, a medicine is used when needed to treat the return of Parkinson’s symptoms. However, since the last century, some doctors have proposed using levodopa to treat albinism. The results of the experiment were not very significant. We research the effects of levodopa on albinism from mechanism of action, clinical trial, molecular mechanism and clinical studies. We find that levodopa has only a weak or no effect on fetuses with albinism.


Keywords


Levodopa, Albinism, GRP143, Pigmentation

Full Text:

PDF

References


Liu Siyin,Kuht Helen J.,Moon Emily Haejoon,Maconachie Gail DE.,Thomas Mervyn G.. Current and Emerging Treatments for Albinism[J]. Survey of Ophthalmology,2020 (prepublish).

C Gail Summers MD,John E Connett PhD,Ann M Holleschau BA,Jennifer L Anderson BS,Inge De Becker MD,Brian S McKay PhD,Murray H Brilliant PhD. Does levodopa improve vision in albinism? Results of a randomized, controlled clinical trial[J]. Clinical & Experimental Ophthalmology,2014,42(8).

Helena Lee,Jennifer Scott,Helen Griffiths,Jay E. Self,Andrew Lotery. Oral levodopa rescues retinal morphology and visual function in a murine model of human albinism[J]. Pigment Cell & Melanoma Research,2019,32(5).

Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS. L-DOPA is an endogenous ligand for OA1. PLoS Biol. 2008; 6: e236.

Espay AJ. Commentary for "Chediak-Higashi syndrome presenting as young-onset levodopa-responsive parkinsonism". Mov Disord. 2013 Feb;28(2):129-30. doi: 10.1002 /mds.25392. PMID: 23436632.

Ilia M, Jeffery G. Retinal cell addition and rod production depend on early stages of ocular melanin synthesis. J Comp Neurol. 2000; 420: 437–444.

Elisabetta De Filippo, Prashiela Manga, Anke C. Schiedel; Identification of Novel G Protein–Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism. Invest. Ophthalmol. Vis. Sci. 2017;58(7):3118-3126. doi: https://doi.org/10.1167/iovs.16-21128.

Self J , Lee H . Novel therapeutics in nystagmus- what has the genetics taught us so far?[J]. 2021.




DOI: http://dx.doi.org/10.18282/rcsm.v3.i2.2236

Refbacks

  • There are currently no refbacks.