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  • Open Access

    Original Research Article

    Article ID: 2350

    Analysis of Risk Factors for Perioperative Sepsis in Urinary Calculi

    by Zhuo Li, Huan Han, Yuyao Zhai, Peng Zhang, Juan Ma, Wanli Duan

    Reports in Clinical Studies and Medicine, Vol.5, No.2, 2023; 76 Views, 18 PDF Downloads

    DOI: https://doi.org/10.18282/rcsm.v3.i2.2350

    The risk factors for perioperative sepsis were investigated in patients with urinary calculi in order to propose targeted interventions. Patients discharged from a 3A hospital with a diagnosis of urinary calculi co-infection in 2020 were retrospectively analyzed and grouped according to whether sepsis occurred in the perioperative period, and the clinical data of the two groups were compared. A total of 435 patients discharged with a diagnosis of urinary calculi co-infection were collected, and urogenic sepsis occurred in 23 cases, with an overall incidence of 5.3%. Univariate analysis showed that gender, abnormal blood leukocyte count on admission, positive urine culture results, carbon dioxide binding capacity and blood creatinine values were risk factors for the development of urogenital sepsis in patients with urinary calculi after surgery ( P<0 .05), while preoperative prophylaxis was a protective factor ( P <0.05). Multifactorial logistic regression analysis showed that preoperative blood leukocyte values, urine culture results, and blood creatinine values were independent risk factors for the development of urogenic sepsis in patients with urinary calculi after surgery.

  • Open Access

    Original Research Article

    Article ID: 2236

    The Effects of Levodopa on Albinism

    by Yi Hao, Huina Ma, Siyuan Wang, Hairu Yan, Wei Zhou

    Reports in Clinical Studies and Medicine, Vol.5, No.2, 2023; 75 Views, 15 PDF Downloads

    DOI: https://doi.org/10.18282/rcsm.v3.i2.2236

    Albinism, a refractory disease with reduced pigmentation. And it has caused great distress to the patient's body and mind. How to treat the disease is a troubling problem in history. Levodopa, a medicine is used when needed to treat the return of Parkinson’s symptoms. However, since the last century, some doctors have proposed using levodopa to treat albinism. The results of the experiment were not very significant. We research the effects of levodopa on albinism from mechanism of action, clinical trial, molecular mechanism and clinical studies. We find that levodopa has only a weak or no effect on fetuses with albinism.

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Research Advancements: Fasting-induced anti-aging molecule keeps blood vessels young

2021-01-25

New research has found that fasting triggers a molecule that can delay the aging of our arteries. The findings could help prevent age-related chronic diseases, such as cancer, cardiovascular disease, and Alzheimer's.

The search for eternal youth has preoccupied the human imagination since the times of Ancient Greece.

In fact, a quick look at Greek mythology shows that youth was more prized than immortality, as some myths tell the story of how futile the latter is if it's not accompanied by the former.

In this regard, modern medicine has recently been catching up with ancient mythology.

Emerging scientific breakthroughs encourage us to hope that the myth of eternal youth will soon become a reality.

In a recent study, researchers were able to reverse signs of aging such as hair loss and wrinkles in mice; and, perhaps more impressively, another team of researchers managed to rejuvenate aging human cells.

Read more about Research Advancements: Fasting-induced anti-aging molecule keeps blood vessels young

VTE in the Critical Care Unit: Risks

2021-01-25

Deep-vein thrombosis (DVT) and pulmonary embolism (PE) contribute significantly to morbidity and mortality associated with critical illness. Among patients who died while in the ICU, PE has been reported in 7 to 27% (mean, 13%) of postmortem examinations, and PE was thought to have caused or contributed to death in 0 to 12% (mean, 3%). A clinical suspicion of PE was present in only 30% of these patients before death.

The vast majority of patients admitted to a critical care unit have a major risk factor for VTE, and most have multiple risk factors. Many of these thrombosis risk factors precede the ICU admission, while others develop during the course of ICU stay. Advanced age, serious medical illnesses Heath Care Mall, and recent surgical procedures or trauma are common in critically ill patients. Sepsis, heart failure, mechanical ventilation, paralysis, surgical interventions, and central venous lines are also common. The importance of each of these clinical risk factors is unknown, as is the role of inherited or acquired coagulation system abnormalities. Factors that have been reported to predict an increased risk of ICU-related VTE include the following: increased age, previous VTE, malignancy, major trauma, prolonged pre-ICU hospital stay, mechanical ventilation, use of paralytic drugs, APACHE (acute physiology and chronic health evaluation) score, need for emergency surgical procedures, insertion of a femoral venous catheter,and failure to use thromboprophylaxis. However, adequately powered studies using multiple logistic regression analysis to determine the independent predictors for thrombosis in critically ill patients have not yet been conducted, to our knowledge.

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