https://ojs.piscomed.com/index.php/gs <table><tbody><tr style="vertical-align: top;"><td style="text-align: justify;"><p><em>General Surgery (GS)</em> is a peer reviewed, Gold open access journal that focuses on publishing the latest developments in surgery and surgical techniques. The journal aims to disseminate valuable information on the various adaptations of commonly performed surgeries around the world. Manuscripts submitted to GS will be subjected to a rigorous editorial checking and a fair peer review upon reception. The whole process will be completed within a month. Accepted manuscripts will be available online immediately, and will soon be officially published by the PiscoMed Publishing. </p></td><td><div id="cover_section"><a title="General Surgery" href="/index.php/gs" target="_self"> <img id="cover-img" src="/public/journals/17/journalThumbnail_en_US.jpg" alt="Clinical Studies" align="right" /> </a><div id="issn_section"><span class="issn_num">ISSN:2529-7732</span><br /><br /> <img src="/public/site/Open_Access.png" alt="" height="20px" /></div></div></td></tr></tbody></table> PiscoMed Publishing Pte Ltd en-US General Surgery 2529-7732 <p>Authors contributing to this journal agree to publish their articles under the <a href="http://creativecommons.org/licenses/by-nc/4.0" target="_blank">Creative Commons Attribution-Noncommercial 4.0 International License</a>, allowing third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit, that the work is not used for commercial purposes, and that in the event of reuse or distribution, the terms of this license are made clear. With this license, the authors hold the copyright without restrictions and are allowed to retain publishing rights without restrictions as long as this journal is the original publisher of the articles.</p><p><img src="/public/site/by-nc.png" alt="" height="30px" /></p> https://ojs.piscomed.com/index.php/gs/article/view/833 <p>In clinical practice, intestinal mucosal inflammation caused by schistosomiasis has great risks to lead to tumor proliferation and migration of cancer cells. Without timely and effective intervention, chronic schistosomiasis infection induced will further deteriorate into colorectal cancer. On the whole, schistosomiasis once caused serious infection to China. Patients suffering from colorectal cancer who have been infected with schistosomiasis can be diagnosed as schistosomiasis-related colorectal cancer if their preoperative intestinal tract has infection manifestations and postoperative pathology indicates that eggs are deposited near the focus. This paper explores the relationship between schistosomiasis and colorectal cancer by combining relevant data and literature at home and abroad.</p> Xingguang Yang Jiwu Yang Xiangnong Cun Pengju Zhao Wei Cheng Haibin Shi Yi Li Copyright (c) 2019 Xingguang Yang et al. https://creativecommons.org/licenses/by-nc/4.0 2023-10-15 2023-10-15 7 1 11 13 10.18282/gs.v3i1.833 https://ojs.piscomed.com/index.php/gs/article/view/852 <p><strong>Objective:</strong> To study the effect and mechanism of chloroquine-induced chemotherapy drugs bleomycin and nedaplatin on apoptosis of tongue squamous cell carcinoma SCC25 cells. <strong>Methods</strong>: The inhibitory effect of different drugs on the growth of SCC25 cells was screened by MTT assay. MTT, Hoechst33258 staining and FCM were used to observe the changes of morphology, cell cycle and apoptosis of SCC25 cells after different treatments. The quantitative analysis of chloroquine induced by Western blot The effect of chemotherapy drugs on the expression of Bax, Bcl-2 and NFkB apoptosis- related proteins in SCC25 cells. <strong>Results</strong>: The proliferation inhibition rate of bleomycin and nedaplatin SCC25 cells induced by chloroquine was significantly higher than that of bleomycin and nedaplatin alone (p&lt;0.05); Hoechst33358 fluorescence staining and flow cytometry showed In the bleomycin group, the apoptotic rate of the chloroquine plus bleomycin group was significantly increased, and the apoptosis rate of the chloroquine + nedaplatin group was significantly higher than that of the nedaplatin group (p&lt;0.05). The proportion of G0/G1 phase in the chloroquine + bleomycin group was higher than that in the bleomycin group (p&lt;0.05), and the ratio of cells in the S phase to the G2/M phase was decreased; the same chloroquine + nedaplatin group G0/G1 The proportion of cells in the period was higher than that in the nedaplatin group (p&lt;0.05), and the proportion of cells in the S phase and G2/M phase decreased. WB results showed that the expression levels of Bax and NFkB in chloroquine + bleomycin group were significantly higher than those in bleomycin group alone, and the expression level of Bcl-2 was lower than that in bleomycin group alone. Bax and NFkB in chloroquine + nedaplatin group The expression level was significantly higher than that of the nedaplatin group alone. The expression level of Bcl-2 was lower than that of the nedaplatin group alone, and the difference was significant (p&lt;0.05). <strong>Conclusion:</strong> Chloroquine induced bleomycin and nedaplatin can significantly inhibit the proliferation of tongue squamous cell carcinoma SCC25 cells, and its proapoptotic effect may be related to the activation of mitochondrial apoptosis-related proteins and nuclear transcription factors.</p> Ruoyu Wang Lan Yang Copyright (c) 2019 Ruoyu Wang and Lan Yang https://creativecommons.org/licenses/by-nc/4.0 2023-10-15 2023-10-15 7 1 14 22 10.18282/gs.v3i1.852 https://ojs.piscomed.com/index.php/gs/article/view/3352 <p>Multiple studies have been conducted to properly elucidate the various tools available to help enhance the resection of tumor tissue, aneurysms, and arteriovenous malformations (AVM). Diffusion tensor imaging (DTI) tractography is useful in providing a map of the tumor borders, allowing the optimal preservation of function and structure of specific regions of the brain. During neurosurgery, especially craniotomies, the possibility of the brain shifting due to swelling or gravity is high. Thus, tools for intraoperative imaging such as high-frequency linear array ultrasound transducers and doppler ultrasonography are utilized for high resolution images and detecting frequency shifts. 4D-digital subtraction angiography (DSA) is another technique used to create spatial resolutions and 3D maps for aneurysms. These similar techniques can also be utilized to assess the integrity of white matter in AVM. By implementing effective evaluation strategies, healthcare professionals can make informed decisions regarding treatment options, preventive measures, and long-term care plans tailored to individual patients.<strong></strong></p> Anjali Patel Drashti Patel Raja Al-Bahou Rajvi Thakkar Ivelina Kioutchoukova Marco Foreman Devon Foster Brandon Lucke-Wold Copyright (c) 2023 Anjali Patel, Drashti Patel, Raja Al-Bahou, Rajvi Thakkar, Ivelina Kioutchoukova, Marco Foreman, Devon Foster, Brandon Lucke-Wold http://creativecommons.org/licenses/by-nc/4.0/ 2023-12-27 2023-12-27 7 1 10.18282/gs.v7i1.3352 https://ojs.piscomed.com/index.php/gs/article/view/851 <p><strong>Background:</strong> Circular Ribonucleic Acid (circRNA) is a type of RNA that has been found in recent years and is a closed loop structure widely found in eukaryotic cells. <strong>Present situation:</strong> The circRNA is stable in nature, highly conserved and tissue and disease specific, and regulates target gene expression at the transcriptional or posttranscriptional level, which is related to the occurrence and development of tumors. YAP (Yes-associated protein) is the main effector of Hippo signaling pathway. It is found that YAP level is closely related to cell proliferation and apoptosis, tissue organ size control and tumorigenesis. <strong>Aim:</strong> to study the correlation between circRNA and YAP in tumors.</p> Xu Li Xiaodong Tian Xiangdong Mu Zhenzhen Liang Xiaohui Xu Haiyun Yu Copyright (c) 2019 Xu Li et al. https://creativecommons.org/licenses/by-nc/4.0 2023-10-15 2023-10-15 7 1 23 29 10.18282/gs.v3i1.851