Circular RNA (circRNA) and YAP in tumor: A review

Xu Li; Xiaodong Tian; Xiangdong Mu; Zhenzhen Liang; Xiaohui Xu; Haiyun Yu

doi:10.18282/gs.v3i1.851

Xu Li Department of Pulmonary, Capital Medical University Electric Power Teaching Hospital
Xiaodong Tian Chinses PLA General Hospital
Xiangdong Mu Pulmonary Department, Beijing Tsinghua Changgung Hospital
Zhenzhen Liang Department of Oncology, Capital Medical University Electric Power Teaching Hospital
Xiaohui Xu Department of Oncology, Capital Medical University Electric Power Teaching Hospital
Haiyun Yu Department of Oncology, Capital Medical University Electric Power Teaching Hospital

Ariticle ID: 851

459 Views, 33 PDF Downloads

DOI: https://doi.org/10.18282/gs.v3i1.851

Keywords: Tumor, circRNA, YAP

Abstract

Background:Â Circular Ribonucleic Acid (circRNA) is a type of RNA that has been found in recent years and is a closed loop structure widely found in eukaryotic cells.Â Present situation:Â The circRNA is stable in nature, highly conserved and tissue and disease specific, and regulates target gene expression at the transcriptional or posttranscriptional level, which is related to the occurrence and development of tumors. YAP (Yes-associated protein) is the main effector ofÂ Hippo signaling pathway. It is found that YAP level is closely related to cell proliferation and apoptosis, tissue organ size control and tumorigenesis.Â Aim:Â to study the correlation between circRNA and YAP in tumors.

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