Circular RNA (circRNA) and YAP in tumor: A review

Xu Li, Xiaodong Tian, Xiangdong Mu, Zhenzhen Liang, Xiaohui Xu, Haiyun Yu


Background: Circular Ribonucleic Acid (circRNA) is a type of RNA that has been found in recent years and is a closed loop structure widely found in eukaryotic cells. Present situation: The circRNA is stable in nature, highly conserved and tissue and disease specific, and regulates target gene expression at the transcriptional or posttranscriptional level, which is related to the occurrence and development of tumors. YAP (Yes-associated protein) is the main effector of Hippo signaling pathway. It is found that YAP level is closely related to cell proliferation and apoptosis, tissue organ size control and tumorigenesis. Aim: to study the correlation between circRNA and YAP in tumors.


Tumor; circRNA; YAP

Full Text:


Included Database


Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 2013; 495(7441):333-8.

Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs. Nat Biotechnol 2014; 32(5):453-61.

Rybak-Wolf A, Stottmeister C, Glazar P, Jens M, Pino N, Giusti S, et al. Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Mol Cell 2015; 58(5):870-85.

Ebert MS, Sharp PA. MicroRNA sponges: progress and possibilities. RNA 2010; 16(11):2043-50.

Ebert MS, Sharp PA. Emerging roles for natural microRNA sponges. Curr Biol 2010; 20(19):R858-61.

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, et al. Natural RNA circles function as efficient micr7.7

Dudekula DB, Panda AC, Grammatikakis I, De S, Abdelmohsen K, Gorospe M. CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs. RNA Biol 2016; 13(1):34-42.

Schneider T, Hung LH, Schreiner S, Starke S, Eckhof H, Rossbach O, et al. CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Sci Rep 2016; 6:31313.

Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, et al. Extensive translation of circular RNAs driven by N(6)-methyladenosine. Cell Res 2017; 27(5):626-41.

Wang K, Long B, Liu F, Wang JX, Liu CY, Zhao B , et al. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Eur Heart J 2016; 37(33):2602-11.

Zhao Y, Alexandrov PN, Jaber V, Lukiw WJ. Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7). Genes (Basel) 2016; 7(12).

Lukiw WJ. Circular RNA (circRNA) in Alzheimer's disease (AD). Front Genet 2013; 4:307.

Junn E, Lee KW, Jeong BS, Chan TW, Im JY, Mouradian MM. Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc Natl Acad Sci U S A 2009; 106(31):13052-7.

Xia W, Qiu M, Chen R, Wang S, Leng X, Wang J, et al. Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation. Sci Rep 2016; 6:35576.

Li P, Chen H, Chen S, Mo X, Li T, Xiao B , et al. Circular RNA 0000096 affects cell growth and migration in gastric cancer. Br J Cancer 2017; 116(5):626-33.

Xu L, Zhang M, Zheng X, Yi P, Lan C, Xu M. The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma. J Cancer Res Clin Oncol 2017; 143(1):17-27.

Zhu M, Xu Y, Chen Y, Yan F. Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer. Biomed Pharmacother 2017; 88:138-44.

Cocquerelle C, Mascrez B, Hetuin D, Bailleul B. Mis-splicing yields circular RNA molecules. FASEB J 1993; 7(1):155-60.

Guo JU, Agarwal V, Guo H, Bartel DP. Expanded identification and characterization of mammalian circular RNAs. Genome Biol 2014; 15(7):409.

Qu S, Yang X, Li X, Wang J, Gao Y, Shang R, et al. Circular RNA: A new star of noncoding RNAs. Cancer Lett 2015; 365(2):141-8.

Westholm JO, Miura P, Olson S, Shenker S, Joseph B, Sanfilippo P, et al. Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation. Cell Rep 2014; 9(5):1966-80.

Talhouarne GJ, Gall JG. Lariat intronic RNAs in the cytoplasm of Xenopus tropicalis oocytes. RNA 2014; 20(9):1476-87.

Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA 2013; 19(2):141-57.

Nabih ES, Andrawes NG. The Association Between Circulating Levels of miRNA-181a and Pancreatic Beta Cells Dysfunction via SMAD7 in Type 1 Diabetic Children and Adolescents. J Clin Lab Anal 2016; 30(5):727-31.

Hansen TB, Kjems J, Damgaard CK. Circular RNA and miR-7 in cancer. Cancer Res 2013; 73(18):5609-12.

Tian F, Wang Y, Xiao Z, Zhu X. [Circular RNA CircHIPK3 Promotes NCI-H1299 and NCI-H2170 Cell Proliferation through miR-379 and its Target IGF1]. Zhongguo Fei Ai Za Zhi 2017; 20(7):459-67.

Du WW, Yang W, Liu E, Yang Z, Dhaliwal P, Yang BB. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res 2016; 44(6):2846-58.

Qu S, Yang X, Li X, Wang J, Gao Y, Shang R, et al. Circular RNA: A new star of noncoding RNAs. Cancer Lett 2015; 365(2):141-8.

Wang Y, Wang Z. Efficient backsplicing produces translatable circular mRNAs. RNA 2015; 21(2):172-9.

Gualandi F, Trabanelli C, Rimessi P, Calzolari E, Toffolatti L, Patarnello T, et al. Multiple exon skipping and RNA circularisation contribute to the severe phenotypic expression of exon 5 dystrophin deletion. J Med Genet 2003; 40(8):e100.

Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, et al. Circular intronic long noncoding RNAs. Mol Cell 2013; 51(6):792-806.

Qu S, Song W, Yang X, Wang J, Zhang R, Zhang Z, et al. Microarray expression profile of circular RNAs in human pancreatic ductal adenocarcinoma. Genomics Data 2015; 5(C):385-7.

Qu S, Song W, Yang X, Wang J, Zhang R, Zhang Z, et al. Microarray expression profile of circular RNAs in human pancreatic ductal adenocarcinoma. Genomics Data 2015; 5(C):385-7.

Li H, Hao X, Wang H, Liu Z, He Y, Pu M, et al. Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. Cellular Physiology & Biochemistry International Journal of Experimental Cellular Physiology Biochemistry & Pharmacology 2016; 40(6):1334.

Xuan L, Qu L, Zhou H, Wang P, Yu H, Wu T, et al. Circular RNA: a novel biomarker for progressive laryngeal cancer. American Journal of Translational Research 2016; 8(2):932.

Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z, et al. Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. Journal of Translational Medicine 2016; 14(1):225.

Zhu M, Xu Y, Chen Y, Yan F. Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017; 88:138.

Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, et al. Circular RNA profile in gliomas revealed by identification tool UROBORUS. Nucleic Acids Research 2016; 44(9):e87-e.

Nair AA, Niu N, Tang X, Thompson KJ, Wang L, Kocher JP , et al. Circular RNAs and their associations with breast cancer subtypes. Oncotarget 2016; 7(49):80967.

Dou Y, Cha DJ, Franklin JL, Higginbotham JN, Jeppesen DK, Weaver AM, et al. Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. Scientific Reports 2016; 6:37982.

Sand M, Bechara FG, Sand D, Gambichler T, Hahn SA, Bromba M , et al. Circular RNA expression in basal cell carcinoma. Epigenomics 2016; 8(5):619-32.

Sand M, Bechara FG, Gambichler T, Sand D, Bromba M, Hahn SA, et al. Circular RNA expression in cutaneous squamous cell carcinoma. Journal of Dermatological Science 2016; 83(3):210-8.

Sui W, Shi Z, Xue W, Ou M, Zhu Y, Chen J, et al. Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. Oncology Reports 2017; 37(3):1804-14.

Chen G, Shi Y, Zhang Y, Sun J. CircRNA_100782 regulates pancreatic carcinoma proliferation through the IL6-STAT3 pathway. OncoTargets and therapy 2017; 10:5783-94.

Xu J, Shu Y, Xu T, Zhu W, Qiu T, Li J, et al. Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma. American journal of translational research 2018; 10(3):771-83.

Shuai M, Hong J, Huang D, Zhang X, Tian Y. Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity. Oncology letters 2018; 16(5):6495-501.

Kim HB, Myung SJ. Clinical implications of the Hippo-YAP pathway in multiple cancer contexts. Bmb Reports 2018; 51(3).

Hsu P-C, You B, Yang Y-L, Zhang W-Q, Wang Y-C, Xu Z, et al. YAP promotes erlotinib resistance in human non-small cell lung cancer cells. Oncotarget 2016; 7(32):51922-33.

Andl T, Zhou L, Yang K, Kadekaro AL, Zhang Y. YAP and WWTR1: New targets for skin cancer treatment. Cancer Letters 2017; 396:30-41.

Zhang Y, Shen H, Withers HG, Yang N, Denson KE, Mussell AL, et al. VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer. Scientific Reports 2017; 7(1):6190.

Ahmed AA, Mohamed AD, Gener M, Li W, Taboada E. YAP and the Hippo pathway in pediatric cancer. Molecular & Cellular Oncology 2017; 4(3):e1295127.

Avril T, Chevet E. Proteostasis trumps YAP in colon cancer. Science Signaling 2015; 8(397):fs18-fs.

Cao L, Sun P-L, Yao M, Jia M, Gao H. Expression of YES-associated protein (YAP) and its clinical significance in breast cancer tissues. Human Pathology 2017; 68:166-74.

Zanconato F, Cordenonsi M, Piccolo S. YAP/TAZ at the Roots of Cancer. Cancer Cell 2016; 29(6):783-803.

Liu G, Huang K, Jie Z, Wu Y, Chen J, Chen Z, et al. CircFAT1 sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells. Mol Cancer 2018; 17(1): 170.

Verduci L, Ferraiuolo M, Sacconi A, Ganci F, Vitale J, Colombo T, et al. The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competentcomplex. Genome Biol 2017; 18(1): 237.

Zhang X, Xu Y, Qian Z, Zheng W, Wu Q, Chen Y, et al. circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma. Cell Death Dis 2018; 9(11): 1091.

Zhang J, Zhao X, Zhang J, Zheng X, Li F. Circular RNA hsa_circ_0023404 exerts an oncogenic role in cervical cancer through regulating miR-136/TFCP2/YAP pathway. Biochem Biophys Res Commun 2018; 501(2): 428-33.

Liu Z, Huang S, Cao Y, Yao Y, Li J, Chen J, et al. YAP1 inhibits circRNA-000425 expression and thus promotes oncogenic activities of miR-17 and miR-106. Biochem Biophys Res Commun 2018; 503(4): 2370-5.

DOI: http://dx.doi.org/10.18282/gs.v3i1.851


  • There are currently no refbacks.