Efficacy of Acupuncture in Treatment of Parkinson's Disease with Orthostatic Hypotension: A Randomized Controlled Clinical Trial
Abstract
Objective: To evaluate the therapeutic effect and safety of acupuncture on Parkinson's disease (PD) with orthostatic hypotension (OH) patients. Methods: A randomized controlled clinical trial was used to observe the efficacy of acupuncture in the treatment of 51 PD with OH patients. The observation time was 1 week. Results: After 1 week of acupuncture treatment, the blood pressure and blood flow velocity of left middle cerebral artery of the treatment group increased compared with the control group, and the difference was statistically significant (P<0.05); the visual vertigo analog scale (VVAS) of the treatment group decreased compared with the control group, and the difference was also statistically significant (P<0.05). After 1 week of acupuncture treatment, the heart rate of the treatment group increased compared with the control group, and the modified Rankin score (mRS) of the treatment group decreased compared with the control group, but there was no statistical difference (P>0.05). There were no serious adverse events and adverse reactions during the observation period. Conclusion: Acupuncture is effective and safe in the treatment of PD with OH.
References
Zhang, Z.X., Roman, G.C., Hong, Z., et al. Parkinson's disease in china: Prevalence in beijing, xian, and shanghai[J]. Lancet,2005,365(9459):595-597.
Velseboer, D.C., DeHaan, R.J., Wieling, W., et al. Prevalence of orthostatic hypotension in parkinson's disease: A systematic review and meta-analysis[J]. Parkinsonism Relat Disord, 2011, 17(10):724-729.
Cutsforth-Gregory J.K., Low, P.A., Neurogenic orthostatic hypotension in parkinson disease: A primer[J]. Neurol Ther,2019,8(2):307-324.
Palma, J.A., Kaufmann, H., Orthostatic hypotension in parkinson disease[J]. Clin Geriatr Med,2020,36(1):53-67.
Merola, A., Sawyer, R.P., Artusi, C.A., et al. Orthostatic hypotension in parkinson disease: Impact on health care utilization[J]. Parkinsonism Relat Disord,2018,47(45-49.
Postuma, R.B., Berg, D., Stern, M., et al. Mds clinical diagnostic criteria for parkinson's disease[J]. Mov Disord,2015,30(12):1591-1601.
Freeman, R., Wieling, W., Axelrod, F.B., et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome[J]. Clin Auton Res,2011,21(2):69-72.
Longhurst, J.C., Tjen-a-Looi, S., Chapter thirteen–acupuncture regulation of blood pressure : Two decades of research[J]. International Review of Neurobiology, 2013, 111(257-271).
Yin, S.D., Cao, Y.J., Zhang, J., Treatment of Primary Hypotension by Electroacupuncture at Neiguan and Gongsun-A Report of 100 cases[J]. Journal of Clinical Acupuncture and Moxibustion,2000,16(2):34-35.
Pan, X.F., Zhou, H.C., Li, C.M., A case report of warm acupuncture at "Baihui", "Neiguan" and "Zusanli" points in the treatment of orthostatic hypotension[J]. Information on Traditional Chinese Medicine, 2012, 29(1):93-94.
Wang, Y., Zhao, J.G., Clinical observation of acupuncture and moxibustion in the treatment of diabetes with orthostatic hypotension[J]. Journal of Emergency Traditional Chinese Medicine,2005,14(5):417-418.
Palma, J.A., Kaufmann, H., Epidemiology, diagnosis, and management of neurogenic orthostatic hypotension [J]. Movement disorders clinical practice, 2017, 4(3):298-308.
Lewitt, P.A., Kymes, S., Hauser, R.A., Parkinson disease and orthostatic hypotension in the elderly: Recognition and management of risk factors for falls[J]. Aging Dis, 2020, 11(3):679-691.
Gibson, J.S., Hunter, C.B., Hewitt, L.A., A call to action: The role of healthcare providers in reducing the burden associated with neurogenic orthostatic hypotension[J]. Neurol Ther,2020,9(2):205-211.
Amjad, F.S., Beinart, S.C., Management of neurogenic orthostatic hypotension in neurodegenerative disorders: A collaboration between cardiology and neurology[J]. Neurol Ther, 2021.
Wu, C.K., Hohler, A.D., Management of orthostatic hypotension in patients with parkinson's disease[J]. Practical neurology, 2015, 15(2): 100-104.
Espay, A.J., Lewitt, P.A., Hauser, R.A., et al. Neurogenic orthostatic hypotension and supine hypertension in parkinson's disease and related synucleinopathies: Prioritisation of treatment targets[J]. The Lancet Neurology, 2016, 15(9):954-966.
Copyright (c) 2023 Yue Liu, Yun Dang, Peng Tang, Jiaxin Zhao, Peipei Li, Hong Wang, Dongliang Wang
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.