PECAM-1 is a Prognostic-Related Biomarker and Correlated with Immune Infiltrates in Breast Cancer

  • Qingfang Yue Department of Medical Oncology, Shaanxi Provincial People's Hospital
  • Yuan Zhang Department of Medical Oncology, Shaanxi Provincial People's Hospital
  • Fei Cao Department of Medical Oncology, Shaanxi Provincial People's Hospital
  • Fei Wang Department of Medical Oncology, Shaanxi Provincial People's Hospital
DOI: https://doi.org/10.18282/pmr.v10i2.2771
Keywords: PECAM-1, Breast Invasive Carcinoma, Prognosis Biomarker, Methylation Immune Infiltration

Abstract

This study aims to analyze the expression and clinical significance of Platelet endothelial cell adhesion molecule 1 (PECAM-1) in breast cancer and the correlation between PECAM-1 and immune infiltrations. We performed a bioinformatic analysis of the prognostic value and immune infiltration correlation of PECAM-1 in breast cancer. The results showed that there were significant differences in PECAM-1 expression levels between breast invasive carcinoma tissues and adjacent normal tissues. The high expression of PECAM-1 was significantly related to favorable overall survival, progression-free survival and distant metastasis free survival in patients with breast cancer. There were significantly positive correlations with the levels of infiltrated B cell, CD4+T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells in breast cancer. In summary, the expression of PECAM-1 can serves as a prognostic biomarker in breast invasive carcinoma and is correlated with immune infiltrates.

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Published
2023-04-19
Issue
Vol. 13 No. 1 (2024)
Section
Original Research Articles

Copyright (c) 2023 Qingfang Yue, Yuan Zhang, Fei Cao, Fei Wang

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