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PECAM-1 is a Prognostic-Related Biomarker and Correlated with Immune Infiltrates in Breast Cancer

Qingfang Yue, Yuan Zhang, Fei Cao, Fei Wang

Abstract


This study aims to analyze the expression and clinical significance of Platelet endothelial cell adhesion molecule 1 (PECAM-1) in breast cancer and the correlation between PECAM-1 and immune infiltrations. We performed a bioinformatic analysis of the prognostic value and immune infiltration correlation of PECAM-1 in breast cancer. The results showed that there were significant differences in PECAM-1 expression levels between breast invasive carcinoma tissues and adjacent normal tissues. The high expression of PECAM-1 was significantly related to favorable overall survival, progression-free survival and distant metastasis free survival in patients with breast cancer. There were significantly positive correlations with the levels of infiltrated B cell, CD4+T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells in breast cancer. In summary, the expression of PECAM-1 can serves as a prognostic biomarker in breast invasive carcinoma and is correlated with immune infiltrates.


Keywords


PECAM-1; Breast Invasive Carcinoma; Prognosis Biomarker; Methylation Immune Infiltration

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References


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DOI: http://dx.doi.org/10.18282/pmr.v10i2.2771

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