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Natural Killer Cells (NK cells) Based Immunotherapy in Treatment of Cancer: Current Progression and Remained Challenges

Shuoming Shang

Abstract


Natural Killer Cells (NK cells) based immunotherapy involving a variety of immune checkpoint inhibitors (ICIs) is becoming increasingly common and has achieved considerable success. However, at the same time, it also faces some huge burning problems. Cancer immunotherapy with NK cells enables the precise elimination of cancer cells. Besides, NK cells can be massively expanded in vitro and do not lead to graft-versus-host-disease (GVHD). Furthermore, ICIs are capable to augment the tumoricidal capacity of NK cells. These characteristics make NK cells dominated immunotherapy a key player in cancer treatment.

Keywords


Natural Killer Cell (NK Cell); Immune Checkpoint Inhibitors (ICIs)

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References


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DOI: http://dx.doi.org/10.18282/pmr.v10i2.2622

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