Regulating Intestinal Microbes to Decrease the Incidence of Heart Disease

  • Xingmei Jin Northeastern University
Ariticle ID: 2365
60 Views, 18 PDF Downloads
Keywords: Intestinal Microbes, Heart Disease, Ways to Reduce TMAO

Abstract

This paper studies the correlation between intestinal microbes and heart disease. In the paper, the process of human body producing Trimethylamine-N-oxide (TMAO) under the role of intestinal microbes has been analyzed, and the ways to reduce the level of TMAO which can increase the incidence of heart disease has been designed. The expected result is that the level of TMAO in plasma is successfully reduced by regulating intestinal microbes. This paper can provide useful information for further studies in self-healing therapy by regulating intestinal microbes.

References

Neish, A. S., “Microbes in Gastrointestinal Health and Disease.†Gastroenterology, 136.1 (2009): 65-80.

Tang, W.H., Wilson, and Stanley, L. Hazen., “The Contributory Role of Gut Microbiota in Cardiovascular Disease.†The Journal of Clinical Investigation124.10 (2014): 4204–4211.

Tang, W.H., Wilson, Wang, Z.N., Bruce, S., Levison, R. A., Koeth, Earl B. Britt, Fu, X.M., Wu, Y.P., and Stanley L. Hazen. “Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk.†The New England Journal of Medicine 368.17 (2013): 1575-584.

Wang, T., Shrestha, Borowski, Wu, Troughton, Klein, and Hazen. “Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure.†Journal of Cardiac Failure 21.2 (2015): 91-96.

Trøseid, Ueland, Hov, Svardal, Gregersen, Dahl, Aakhus, Gude, Bjørndal, Halvorsen, Karlsen, Aukrust, Gullestad, Berge, and Yndestad. “Microbiotaâ€dependent Metabolite Trimethylamineâ€Nâ€oxide Is Associated with Disease Severity and Survival of Patients with Chronic Heart Failure.†Journal of Internal Medicine 277.6 (2015): 717-26.

Wang, Z.N., Elizabeth Klipfell, Brian J. Bennett, Robert Koeth, Bruce S. Levison, Brandon Dugar, Ariel E. Feldstein, Earl B. Britt, Fu, X.M., Chung, Y.M., Wu, Y.P., Phil Schauer, Jonathan D. Smith, Hooman Allayee, W. H. Wilson Tang, Joseph A. Didonato, Aldons J. Lusis, and Stanley L. Hazen. “Gut Flora Metabolism of Phosphatidylcholine Promotes Cardiovascular Disease.†Nature 472.7341 (2011): 57-63.

Published
2023-04-19
How to Cite
Jin, X. (2023). Regulating Intestinal Microbes to Decrease the Incidence of Heart Disease. Preventive Medicine Research, 12(1), 1-4. https://doi.org/10.18282/pmr.v10i2.2365
Section
Original Research Article