Effects of Wu’s Long-Snake-Like Moxibustion on post-stroke cancer patients

  • Zhongqiong Li Health Care Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
  • Yumei Chen Health Care Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
  • Mingyue Li Health Care Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China
Article ID: 4154
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Keywords: Wu’s Long-Snake-Like Moxibustion; stroke; cancer patients; psychological distress; sleep disorders; quality of life; hypertension

Abstract

Background: Due to the combined effects of stroke and cancer treatment, post-stroke cancer patients face the multiple burdens of psychological distress, sleep disorders, and declined quality of life. Wu’s Long-Snake-Like Moxibustion, a therapeutic approach combining traditional Chinese medicine and modern medical concepts, aims to alleviate these challenges by regulating qi and blood through acupoint stimulation. This study explored the effects of Wu’s Long-Snake-Like Moxibustion on psychological distress, sleep disorders, and quality of life in post-stroke cancer patients, with a specific focus on hypertension as a comorbidity. Methods: A case-control study recruited 60 participants who were assigned to either the treatment group (Wu’s Long-Snake-Like Moxibustion) or the control group (standard care). Psychological distress, sleep quality, and quality of life were assessed using standardized scales, including the Hospital Anxiety and Depression Scale (HADS), Generalized Anxiety Disorder-7 (GAD-7), Pittsburgh Sleep Quality Index (PSQI), and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). Blood pressure was measured at baseline and at 12 weeks. Paired t-tests were used for intra-group comparisons, and independent t-tests were applied for inter-group differences. Results: At 12 weeks, the treatment group showed significant improvements on all measures. Anxiety (HADS-A) decreased from 14.2 (SD = 3.4) to 5.1 (SD = 2.0) (p = 0.02), and sleep quality (PSQI) improved from 8.7 (SD = 2.3) to 3.2 (SD = 1.6) (p < 0.0001). Quality of life, including physical (from 57.3 to 85.4) and emotional (from 45.8 to 80.1), significantly improved (p = 0.01 and p = 0.002, respectively). Blood pressure reductions in the treatment group were also significant, with systolic pressure dropping from 142.3 (SD = 12.5) to 118.6 (SD = 8.9) (p = 0.001). In contrast, the control group showed modest improvements in anxiety (from 13.9 to 10.4), sleep quality (from 8.3 to 6.7), and blood pressure (from 140.8 to 133.2). Conclusion: Wu’s Long-Snake-Like Moxibustion not only significantly improved the psychological distress, sleep quality, and quality of life of post-stroke cancer patients but also effectively reduced hypertension. These findings suggest that Wu’s Long-Snake-Like Moxibustion may be an effective complementary therapy for managing the complex needs of this patient population.

Published
2025-07-07
How to Cite
Li, Z., Chen, Y., & Li, M. (2025). Effects of Wu’s Long-Snake-Like Moxibustion on post-stroke cancer patients. Psycho-Oncologie, 19(3), 4154. https://doi.org/10.18282/po4154
Section
Article

References

1. Zuber M. Stroke and cancer. Revue Neurologique. 2023; 179(5): 417–424. doi: 10.1016/j.neurol.2023.03.009

2. Kawano T, Mackman N. Cancer patients and ischemic stroke. Thrombosis Research. 2024; 237: 155–162. doi: 10.1016/j.thromres.2024.03.019

3. Navi BB, Kasner SE, Elkind MSV, et al. Cancer and Embolic Stroke of Undetermined Source. Stroke. 2021; 52(3): 1121–1130. doi: 10.1161/STROKEAHA.120.032002

4. Lun R, Siegal D, Ramsay T, Dowlatshahi D. Cancer and stroke: What do we know and where do we go? Thrombosis Research. 2022; 219: 133–140. doi: 10.1016/j.thromres.2022.09.014

5. Costamagna G, Navi BB, Beyeler M, et al. Ischemic Stroke in Cancer: Mechanisms, Biomarkers, and Implications for Treatment. Seminars in Thrombosis and Hemostasis. 2024; 50(3): 342–359. doi: 10.1055/s-0043-1771270

6. Hurford R, Strowd RE 3rd. Cancer and Stroke: A Relationship Thicker Than Blood. Neurology. 2021; 96(4): 143–144. doi: 10.1212/WNL.0000000000011263

7. Yang Y, Huang X, Wang Y, et al. The impact of triglyceride-glucose index on ischemic stroke: a systematic review and meta-analysis. Cardiovascular Diabetology. 2023; 22(1): 2. doi: 10.1186/s12933-022-01732-0

8. Muhandiramge J, Zalcberg JR, Warner ET, et al. Cardiovascular disease and stroke following cancer and cancer treatment in older adults. Cancer. 2024; 130(23): 4138–4148. doi: 10.1002/cncr.35503

9. Suárez-Pérez A, Macias-Gómez A, Fernández-Pérez I, et al. Epigenetic age and long-term cancer risk following a stroke. Genome Medicine. 2024; 16(1): 135. doi: 10.1186/s13073-024-01408-2

10. Sun MY, Bhaskar SMM. When Two Maladies Meet: Disease Burden and Pathophysiology of Stroke in Cancer. International Journal of Molecular Sciences. 2022; 23(24): 15769. doi: 10.3390/ijms232415769

11. Yip PL, Zheng H, Cheo T, et al. Stroke Risk in Survivors of Head and Neck Cancer. JAMA Netw Open. 2024; 7(2): e2354947. doi: 10.1001/jamanetworkopen.2023.54947

12. Smith J, Margalit D, Golledge J, et al. Carotid Artery Stenosis and Ischemic Stroke in Patients With Head and Neck Cancer Treated With Radiation Therapy: A Critical Review. International Journal of Radiation Oncology, Biology, Physics. 2024; 119(5): 1437–1454. doi: 10.1016/j.ijrobp.2024.03.044

13. Sun MY, Bhaskar SMM. Bridging the Gap in Cancer-Related Stroke Management: Update on Therapeutic and Preventive Approaches. International Journal of Molecular Sciences. 2023; 24(9): 7981. doi: 10.3390/ijms24097981

14. Huo J, Zhou J, Han Y, et al. Wu Zhongchao’s experience in treatment of allergic rhinitis by acupuncture-moxibustion at “band-like function zone of back-shu points”. Zhongguo Zhen Jiu. 2024; 44(2): 191–194. doi: 10.13703/j.0255-2930.20230528-k0003

15. Peng S, Zhang SQ, Wang YL. Research Progress of Moxibustion in Improving Postoperative Discomfort of Breast Cancer Patients. TMR Cancer. 2021; 4(5): 23. doi: 10.53388/TMRC20210405023

16. Guo SQ, Zhao GZ, Li ST, et al. Moxibustion for treating patients with post-stroke depression: a systematic review and meta-analysis. Annals of Palliative Medicine. 2022; 11(1): 85–97. doi: 10.21037/apm-21-3421

17. Zhang Y, He X, Hu S, et al. Efficacy and safety of massage in the treatment of post-stroke insomnia: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020; 99(51): e23598. doi: 10.1097/MD.0000000000023598

18. Liu F, Lyu Z, Lin S, et al. Effects of moxibustion on cognition and activities of daily living in post-stroke cognitive impairment: A systematic review and meta-analysis of randomized controlled trials. Journal of Nursing Scholarship. 2023; 55(2): 464–476. doi: 10.1111/jnu.12846

19. Dai XQ, Lv P, Huang RZ, et al. Moxibustion Strategies for Mice. Journal of Visualized Experiments. 2022; 7: 179. doi: 10.3791/63119

20. Jia Z, Yu W, Li X, et al. Du-moxibustion ameliorates depression-like behavior and neuroinflammation in chronic unpredictable mild stress-induced mice. Journal of Affective Disorders. 2024; 358: 211–221. doi: 10.1016/j.jad.2024.05.025

21. Lu S, Wang B, Wang J, et al. Moxibustion for the Treatment of Cancer and its Complications: Efficacies and Mechanisms. Integrative Cancer Therapies. 2023; 22: 15347354231198089. doi: 10.1177/15347354231198089

22. Aum S, Choe S, Cai M, et al. Moxibustion for cognitive impairment: a systematic review and meta-analysis of animal studies. Integrative Medicine Research. 2021; 10(2): 100680. doi: 10.1016/j.imr.2020.100680

23. Su XT, Wang L, Ma SM, et al. Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke. Oxidative Medicine and Cellular Longevity. 2020; 2020: 7875396. doi: 10.1155/2020/7875396

24. Chaoran LI, Yan Y, Chuwen F, et al. Integrated ‘omics analysis for the gut microbiota response to moxibustion in a rat model of chronic fatigue syndrome. Journal of Traditional Chinese Medicine. 2023; 43(6): 1176–1189. doi: 10.19852/j.cnki.jtcm.20231018.004

25. Wang JY, Zhang Y, Chen Y, et al. Mechanisms underlying antidepressant effect of transcutaneous auricular vagus nerve stimulation on CUMS model rats based on hippocampal α7nAchR/NF-κB signal pathway. Journal of Neuroinflammation. 2021; 18(1): 291. doi: 10.1186/s12974-021-02341-6

26. Chen Y, Zhang Y, Wang J, et al. Anti-neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression-like behaviors via hypothalamic α7nAchR/JAK2/STAT3/NF-κB pathway in rats exposed to chronic unpredictable mild stress. CNS Neuroscience & Therapeutics. 2023; 29(9): 2634–2644. doi: 10.1111/cns.14207

27. Sinopoulou V, Gordon M, Akobeng AK, et al. Interventions for the management of abdominal pain in Crohn’s disease and inflammatory bowel disease. Cochrane Database of Systematic Reviews. 2021; 11(11): CD013531. doi: 10.1002/14651858.CD013531.pub2

28. Liang S, Yin Y, Zhang Z, et al. Moxibustion prevents tripterygium glycoside-induced oligoasthenoteratozoospermia in rats via reduced oxidative stress and modulation of the Nrf2/HO-1 signaling pathway. Aging. 2024; 16(3): 2141–2160. doi: 10.18632/aging.205475

29. Zhou Z, Zhang Y, Deng H, et al. Comparison of acupuncture and moxibustion related non-surgical therapies for women with stress urinary incontinence: A systematic review and network meta-analysis of randomized controlled trials. Explore. 2024; 20(4): 493–500. doi: 10.1016/j.explore.2023.11.010

30. Yin HN, Cui Y, Sun ZR, et al. Research progress on the effect mechanism of acupuncture-moxibustion for pressure injuries. Zhongguo Zhen Jiu. 2023; 43(8): 970–976. doi: 10.13703/j.0255-2930.20221013-k0001

31. Zeng H, Zhuang Y, Yan X, et al. Machine learning-based identification of novel hub genes associated with oxidative stress in lupus nephritis: Implications for diagnosis and therapeutic targets. Lupus Science & Medicine. 2024; 11(1): e001126. doi: 10.1136/lupus-2023-001126

32. Shin KM, Park JE, Yook TH, et al. Moxibustion for prehypertension and stage I hypertension: A pilot randomized controlled trial. Integrative Medicine Research. 2019; 8(1): 1–7. doi: 10.1016/j.imr.2018.11.002

33. Fan C, Yang X, Yan L, Shi Z. Oxidative stress is two-sided in the treatment of acute myeloid leukemia. Cancer Medicine. 2024; 13(9): e6806. doi: 10.1002/cam4.6806

34. Wang X, Ji H, Yang Y, et al. Moxibustion Regulates the BRG1/Nrf2/HO-1 Pathway by Inhibiting MicroRNA-222-3p to Prevent Oxidative Stress in Intestinal Epithelial Cells in Ulcerative Colitis and Colitis-Associated Colorectal Cancer. Journal of Immunology Research. 2024; 2024: 8273732. doi: 10.1155/2024/8273732

35. Chang J, Jiang T, Shan X, et al. Pro-inflammatory cytokines in stress-induced depression: Novel insights into mechanisms and promising therapeutic strategies. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2024; 131: 110931. doi: 10.1016/j.pnpbp.2023.110931

36. Pan MM, Wang QY, Hou JL, et al. Effects of umbilical moxibustion on phobic behavior and monoamine neurotransmitters in stress-model rats. Zhongguo Zhen Jiu. 2023; 43(2): 191–196. doi: 10.13703/j.0255-2930.20211123-k0004

37. Lu CX, Xu Q, Ye RL, et al. Moxibustion of 45 ℃ at “Zusanli” (ST36) improves vascular endothelial oxidative stress in hyperlipidemia rats. Zhen Ci Yan Jiu. 2023; 48(4): 331–338. doi: 10.13702/j.1000-0607.20220056

38. Wang H, Xia R, Gao B, et al. Effect of moxibustion combined with intraperitoneal injection of benazepril on endoplasmic reticulum stress-related protein phosphorylation in rats with chronic heart failure. Zhen Ci Yan Jiu. 2024; 49(3): 231–237. doi: 10.13702/j.1000-0607.20221265

39. Wang LL, Ren ZX, Zhu JY, et al. Efficacy of electroacupuncture combined with penetrating moxibustion for postpartum stress urinary incontinence. Zhongguo Zhen Jiu. 2019; 39(6): 599–603. doi: 10.13703/j.0255-2930.2019.06.008

40. Yang J, Liu S, Hu S, et al. Moxibustion’s protective role against atherosclerosis: Inhibition of Ca2+ overload-triggered oxidative stress and inflammatory response via P2Y12/PI3K/AKT pathway. Environmental Toxicology. 2024; 39(1): 228–237. doi: 10.1002/tox.23961