The effects of mindfulness meditation combined with happiness therapy on the psychological status and survival of patients with middle and advanced non-small cell lung cancer

  • Yang Yu The Affiliated Xuzhou Clinical College of Xuzhou Medical University, Xuzhou 221009, China; Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou 221009, China
  • Enhui Liu The Affiliated Xuzhou Clinical College of Xuzhou Medical University, Xuzhou 221009, China
  • Juan Zhou Department of Laboratory Medicine, Xuzhou Central Hospital, Xuzhou 221009, China
  • Qingqing Zhao Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou 221009, China
  • Rudan Deng The Affiliated Xuzhou Clinical College of Xuzhou Medical University, Xuzhou 221009, China
  • Qing Li Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou 221009, China
  • Yong Liu Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou 221009, China
Article ID: 3638
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Keywords: mindfulness meditation; psychological resilience; progression-free survival; lung cancer; anxiety; general well-being

Abstract

Objective: The study aimed to investigate the effectiveness of the intervention on psychological resilience, negative emotions, and overall well-being of subjects with non-small cell lung cancer (NSCLC) in middle and advanced stages utilizing happiness therapy combined with positive thinking-meditation expected to provide a basis for clinical psychological intervention. Methods: One hundred patients with stage III/IV SCLC were chosen as the study population. The participants were assigned into two groups randomly, depending on a random number table: a control cohort (n = 50) and an intervention cohort (n = 50). The control group received systemic anti-tumour therapy and daily care, while the intervention group received an additional 4-week psychosocial intervention of happiness therapy and positive thinking meditation on top of the systemic anti-tumour therapy and daily care. The study used the Hospital Anxiety and Depression Scale (HADS), the Psychological Resilience Scale (CD-RISC), and the General Well-Being Scale (GWB) as assessment tools to comprehensively evaluate psychological state before and after therapy, respectively. Patients in the 2 groups were also reviewed at a 6-month follow-up to record progression-free survival (PFS) in both groups. Results: Data analysis illustrated that following intervention, the psychological resilience score (78.30 ± 8.47) and the general well-being score (81.06 ± 3.43) of the patients within the intervention cohort were significantly higher than the control (t = −11.13, −10.14, P < 0.001). Anxiety and depression scores in patients of the intervention group (17.80 ± 3.47) were notably lower than those in the control group (t = 5.30, P < 0.001), and there was a different median progression-free survival (PFS) time (171.00 vs. 219.00 days, P = 0.037). Conclusion: Present study demonstrated that happiness therapy combined with positive thinking meditation as psychological intervention can improve psychological resilience caused by middle- and late-stage NSCLC effectively, reduce their negative emotions, significantly enhance their overall sense of well-being, delay disease progression.

Article Status
In press
How to Cite
Yu, Y., Liu, E., Zhou, J., Zhao, Q., Deng, R., Li, Q., & Liu, Y. (2025). The effects of mindfulness meditation combined with happiness therapy on the psychological status and survival of patients with middle and advanced non-small cell lung cancer. Psycho-Oncologie, 3638. https://doi.org/10.18282/po3638
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References

Han B, Zheng R, Zeng H, et al. Cancer incidence and mortality in China, 2022. Journal of the National Cancer Center. 2024; 4(1): 47-53. doi: 10.1016/j.jncc.2024.01.006

Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. Nature. 2018; 553(7689): 446-454. doi: 10.1038/nature25183

Chen S, Mei R, Tan C, et al. Psychological resilience and related influencing factors in postoperative non‐small cell lung cancer patients: A cross‐sectional study. Psycho-Oncology. 2020; 29(11): 1815-1822. doi: 10.1002/pon.5485

Ristevska-Dimitrovska G, Filov I, Rajchanovska D, et al. Resilience and Quality of Life in Breast Cancer Patients. Open Access Macedonian Journal of Medical Sciences. 2015; 3(4): 727-731. doi: 10.3889/oamjms.2015.128

Joyce S, Shand F, Tighe J, et al. Road to resilience: a systematic review and meta-analysis of resilience training programmes and interventions. BMJ Open. 2018; 8(6): e017858. doi: 10.1136/bmjopen-2017-017858

Wu Y, Luo X, Zhou Q, et al. The disbalance of LRP1 and SIRPα by psychological stress dampens the clearance of tumor cells by macrophages. Acta Pharmaceutica Sinica B. 2022; 12(1): 197-209. doi: 10.1016/j.apsb.2021.06.002

Carlson LE, Doll R, Stephen J, et al. Randomized Controlled Trial of Mindfulness-Based Cancer Recovery Versus Supportive Expressive Group Therapy for Distressed Survivors of Breast Cancer (MINDSET). Journal of Clinical Oncology. 2013; 31(25): 3119-3126. doi: 10.1200/jco.2012.47.5210

Gouldthorpe C, Power J, Davies A. Circadian rhythm disorders in patients with advanced cancer: a scoping review. Frontiers in Oncology. 2023; 13. doi: 10.3389/fonc.2023.1240284

Carlson LE, Beattie TL, Giese‐Davis J, et al. Mindfulness‐based cancer recovery and supportive‐expressive therapy maintain telomere length relative to controls in distressed breast cancer survivors. Cancer. 2014; 121(3): 476-484. doi: 10.1002/cncr.29063

Zeng Y, Hu CH, Li YZ, et al. Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer. Nature Medicine. 2024; 30: 1680-1688. doi: 10.1038/s41591-024-02929-4

Hsieh CC, Ho CC, Lin ZZ, et al. Trait mindfulness and depressive symptoms in non-small cell lung cancer patients: the mediating roles of quality of life and meaning in life. Psychology & Health. 2020; 36(9): 1102-1114. doi: 10.1080/08870446.2020.1825713

Zhang Q, Zhao H, Zheng Y. Effectiveness of mindfulness-based stress reduction (MBSR) on symptom variables and health-related quality of life in breast cancer patients—a systematic review and meta-analysis. Supportive Care in Cancer. 2018; 27(3): 771-781. doi: 10.1007/s00520-018-4570-x

Carletto S, Tesio V, Borghi M, et al. The Effectiveness of a Body-Affective Mindfulness Intervention for Multiple Sclerosis Patients with Depressive Symptoms: A Randomized Controlled Clinical Trial. Frontiers in Psychology. 2017; 8. doi: 10.3389/fpsyg.2017.02083

Farias M, Maraldi E, Wallenkampf KC, et al. Adverse events in meditation practices and meditation‐based therapies: a systematic review. Acta Psychiatrica Scandinavica. 2020; 142(5): 374-393. doi: 10.1111/acps.13225

Malins S, Biswas S, Rathbone J, et al. Reducing dropout in acceptance and commitment therapy, mindfulness‐based cognitive therapy, and problem‐solving therapy for chronic pain and cancer patients using motivational interviewing. British Journal of Clinical Psychology. 2020; 59(3): 424-438. doi: 10.1111/bjc.12254

Carlson LE, Speca M, Patel KD, et al. Mindfulness-Based Stress Reduction in Relation to Quality of Life, Mood, Symptoms of Stress, and Immune Parameters in Breast and Prostate Cancer Outpatients. Psychosomatic Medicine. 2003; 65(4): 571-581. doi: 10.1097/01.psy.0000074003.35911.41

van der Lee ML, Garssen B. Mindfulness‐based cognitive therapy reduces chronic cancer‐related fatigue: a treatment study. Psycho-Oncology. 2010; 21(3): 264-272. doi: 10.1002/pon.1890

Lengacher CA, Reich RR, Paterson CL, et al. Examination of Broad Symptom Improvement Resulting From Mindfulness-Based Stress Reduction in Breast Cancer Survivors: A Randomized Controlled Trial. Journal of Clinical Oncology. 2016; 34(24): 2827-2834. doi: 10.1200/jco.2015.65.7874

Faghani F, Choobforoushzadeh A, Sharbafchi MR, et al. Effectiveness of mindfulness-based supportive psychotherapy on posttraumatic growth, resilience, and self-compassion in cancer patients. Wiener klinische Wochenschrift. 2022; 134(15-16): 593-601. doi: 10.1007/s00508-022-02057-4

Tian X, Yi LJ, Liang CSS, et al. The Impact of Mindfulness-Based Stress Reduction (MBSR) on Psychological Outcomes and Quality of Life in Patients With Lung Cancer: A Meta-Analysis. Frontiers in Psychology. 2022; 13. doi: 10.3389/fpsyg.2022.901247

Fava GA. Well-Being Therapy: Conceptual and Technical Issues. Psychotherapy and Psychosomatics. 1999; 68(4): 171-179. doi: 10.1159/000012329

Cheng C, Dong D, He J, et al. Psychometric properties of the 10-item Connor–Davidson Resilience Scale (CD-RISC-10) in Chinese undergraduates and depressive patients. Journal of Affective Disorders. 2020; 261: 211-220. doi: 10.1016/j.jad.2019.10.018

Annunziata MA, Muzzatti B, Bidoli E, et al. Hospital Anxiety and Depression Scale (HADS) accuracy in cancer patients. Supportive Care in Cancer. 2019; 28(8): 3921-3926. doi: 10.1007/s00520-019-05244-8

Duan J. Results and analyses of the General Happiness Scale among college students in China. Chinese Journal of Clinical Psychology. 1996; 4(1): 56-57.

Wei Y, Zhu DQ, Li YM. Progress of research on the impact of psychological resilience on health outcomes in adults with chronic diseases. Chinese Journal of Practical Nursing. 2019; 35(5): 391.

Boyle CC, Stanton AL, Ganz PA, et al. Improvements in emotion regulation following mindfulness meditation: Effects on depressive symptoms and perceived stress in younger breast cancer survivors. Journal of Consulting and Clinical Psychology. 2017; 85(4): 397-402. doi: 10.1037/ccp0000186

Fava GA, Cosci F, Guidi J, et al. Well-being therapy in depression: New insights into the role of psychological well-being in the clinical process. Depression and Anxiety. 2017; 34(9): 801-808. doi: 10.1002/da.22629

Chudzicka-Czupała A, Zalewska-Łunkiewicz K. Subjective well-being, general self-efficacy and coping with stress in former psychiatric patients preparing for the peer support role: an exploratory study. Health and Quality of Life Outcomes. 2020; 18(1). doi: 10.1186/s12955-020-01348-6

McDonough MH, Sabiston CM, Wrosch C. Predicting changes in posttraumatic growth and subjective well-being among breast cancer survivors: the role of social support and stress. Psycho-Oncology. 2013; 23(1): 114-120. doi: 10.1002/pon.3380

Yang YL, Liu L, Wang Y, et al. The prevalence of depression and anxiety among Chinese adults with cancer: a systematic review and meta-analysis. BMC Cancer. 2013; 13(1). doi: 10.1186/1471-2407-13-393

Ruini C, Fava GA. Well‐being therapy for generalized anxiety disorder. Journal of Clinical Psychology. 2009; 65(5): 510-519. doi: 10.1002/jclp.20592

Gok Metin Z, Karadas C, Izgu N, et al. Effects of progressive muscle relaxation and mindfulness meditation on fatigue, coping styles, and quality of life in early breast cancer patients: An assessor blinded, three-arm, randomized controlled trial. European Journal of Oncology Nursing. 2019; 42: 116-125. doi: 10.1016/j.ejon.2019.09.003

Walker J, Magill N, Mulick A, et al. Different independent associations of depression and anxiety with survival in patients with cancer. Journal of Psychosomatic Research. 2020; 138: 110218. doi: 10.1016/j.jpsychores.2020.110218