The Introduction of the Special Issue

 In recent years, with the deep research of nano-drug carriers, the environmental responsive inorganic-organic composite nanoparticles have been widely applied in drug delivery systems. These intelligent nano-drug carriers possessed unique advantages. Nano-drug carriers not only effectively enhanced the solubility and chemical stability of hydrophobic drugs, but also with the various physiological environment (pH and temperature) could control drug release behavior to achieve the targeted drug delivery in the lesion site, thereby enhancing the efficacy and reducing its toxicity for normal tissue. As an excellent nano-drug carrier with well biocompatibility and low toxicity, high surface areas and large pore volume, mesoporous silica nanoparticles (MSNs) can be carried out to effectively improve drug loading capacity through physical or chemical modification and thereafter to form mesoporous nanocomposites with environmental sensitivity.

Based on current research backgrounds, in this special thesis, MSNs core as “storage” achieved the high drug loading capability, and the pH- and temperature- dual stimuli responsive copolymer shell as “valve”, the core-shell structured nanocompites (P@MSNs) were evaluated, and the controlled drug delivery were explored with pH- and temperature- dual stimuli responsive behaviors. In addition, the influence of composition and content of shell and the particle size of core on the properties of drug loading and release has been demonstrated. The main contents are summarized as follows:

1. Preparation of dual pH/temperature responsive mesoporous silica-based composite nanoparticles.

2. Regulation/fractal characteristics of coated-polymeric shell in pH/temperature environmental sensitive composite nanoparticles.

3. Influences of copolymer shell thickness and MSN core size on pH/temperature environmental sensitives and controlled release properties.


The Research Scope of the Special Issue

· copolymers

· mesoporous silicas

· core-shell structures

· drug delvery

· characterizations


The Article Title of the Special Issue

1: Research progress of drug release in application environmental temperature/dual responsive copolymer in nano-drug delivery system

2: Structure and mechanism of pH/temperature dual responsive (N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA) polymers

3: Fractal evolution of dual pH- and temperature-responsive P(NIPAM-co-AA)@MSNs with controlled mesoporous silica core and coated-copolymer shell during drug delivery procedure via SAXS characterization

4: Mutlifunctional mesoporous ZnO@MSNs with strong fluorescence and high loaded capacity for sustained drug release

5: Regulating dual temperature- and pH-responsibility constructed from core-shell mesoporous hybrid silica (P(NIPAM-co-AA)@BMMs) via adjusting AA incorporation onto NIPAM

6: Influence of ionic strength on the pH-sensitive in vitro ibuprofen release from dextran-poly(acrylic acid) copolymer

7: P(NIPAM-co-AA)@MSNs with controlled copolymer shell and its fractal characteristics for dual pH- and temperature-responsive performance of ibuprofen release


Submission guidelines

All papers should be submitted via the Materials Physics and Chemistry submission system:


Submitted articles should not be published or under review elsewhere. All submissions will be subject to the journal’s standard peer review process. Criteria for acceptance include originality, contribution, scientific merit and relevance to the field of interest of the Special Issue.


Important Dates

Paper Submission Due: April 20 ,2020


The Lead Guest Editor

Jihong Sun