Psycho-Oncologie

Effects and mechanisms of CBT-based psychological nursing for anxiety/depression in diabetes-pancreatic cancer patients

2025-07-03T00:45:55+00:00

Background: Type 2 diabetes mellitus (T2DM) complicated by pancreatic cancer is associated with a high prevalence of anxiety and depression, yet current treatments predominantly focus on physiological management. Consequently, there is an urgent need for effective psychological nursing interventions to address emotional distress and improve overall patient outcomes. Objective: The objective of this study is to explore the impact of psychological nursing interventions grounded in Cognitive Behavioral Therapy (CBT) on alleviating anxiety and depression symptoms in patients with Type 2 diabetes mellitus (T2DM) who are also facing complications from pancreatic cancer. Additionally, we aim to examine the cognitive regulation mechanisms involved in this process. Methods: A prospective randomized controlled trial was carried out with 78 patients diagnosed with type 2 diabetes mellitus (T2DM) who also had pancreatic cancer. The participants were randomly assigned to either an intervention group or a control group, each consisting of 39 individuals. The control group received standard medical care and routine nursing, while the intervention group participated in a 12-week cognitive-behavioral therapy (CBT) psychological nursing intervention alongside standard care, followed by a 12-month follow-up. Various factors, including anxiety, depression, cognitive regulation strategies, quality of life, self-efficacy, and clinical indicators, were evaluated at baseline, after the intervention, and during the follow-up period. The effectiveness of the intervention was analyzed using repeated measures analysis of variance. Results: The patients in the intervention group experienced a marked reduction in anxiety (HADS-A) and depression (HADS-D) scores when compared to the control group, with a statistically significant difference (p < 0.001). Additionally, there was a notable enhancement in cognitive regulation abilities, as evidenced by higher scores on the Cognitive Emotion Regulation Questionnaire (CERQ) and lower scores on the Automatic Thoughts Questionnaire (ATQ) relative to the control group (p < 0.001). Over time, both quality of life (measured by the EORTC QLQ-C30) and self-efficacy (assessed by the GSES) scores showed significant improvement, with clear distinctions between the two groups (p < 0.001). Furthermore, clinical indicators such as fasting blood glucose, HbA1c, and CA19-9 levels demonstrated more substantial improvements in the intervention group compared to the control group (p < 0.01). Conclusion: CBT psychological nursing significantly alleviated anxiety and depression symptoms in patients with T2DM complicated by pancreatic cancer, optimized cognitive regulation mechanisms, improved quality of life and self-efficacy, and indirectly enhanced metabolic and tumor marker levels. These findings underscore its significant clinical application value.

Clinical practice and research on the psychological cognitive ability under the IKAP model in postoperative flap healing and psychological influencing factors in breast cancer

2025-07-04T03:36:12+00:00

Objective: To investigate the impact of psychological cognitive ability on flap healing and psychological factors in postoperative breast cancer (BC) individuals under the Information-Knowledge-Attitude-Practice (IKAP) model. Methods: A total of 123 postoperative BC individuals treated at our hospital between April 2022 and April 2023 were selected for the study. They were randomly assigned into a control group (CG, routine nursing model, n = 61) and an observation group (OG, IKAP model-based psychological cognitive ability intervention, n = 62) using a random number table method. The observation group, on the basis of routine care, combined the IKAP model for psychological and cognitive ability intervention. This included providing personalized health education information, enhancing the patients’ knowledge level, changing their attitudes towards the disease, and promoting the implementation of healthy behaviors through psychological counseling and practical training. The healing rates, healing times, and differences in cognitive ability, psychological status, and quality of life scores before and after the intervention were compared involving the two groupings. The impact of cognitive ability on flap healing and psychological factors was also analyzed. Results: After 2 weeks of intervention, the healing rate in the OG was higher than that of the CG [72.58% (45/62) vs. 54.10% (33/61)] (χ² = 4.527, P = 0.033). The healing time in the OG was shorter than in the CG, but the difference was not considerable (P > 0.05). After 2 weeks of intervention, the two groups showed differences in their Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) scores [(7.73 ± 1.61) vs. (6.08 ± 1.53)], and Functional Assessment of Cancer Therapy-Breast (FACT-B) scores [(92.38 ± 6.43)], with the OG showing more significant improvements (P < 0.05). Compared to the unhealed group, the healed group had higher FACT-Cog and FACT-B scores, and lower HADS scores (P < 0.05). Cognitive ability directly predicted flap healing (β = 0.521, P < 0.001) and also influenced it indirectly through psychological factors (β = 0.537, P < 0.001). The mediating effect of psychological factors accounted for 69.17%, and the direct effect of cognitive ability accounted for 30.65%. This shows that cognitive ability affects flap healing both directly and indirectly through psychological changes. Conclusion: The IKAP model can significantly enhance patients’ cognitive ability and quality of life, shorten healing time, and, through the mediation of psychological factors, further promote flap healing. This provides a new perspective and method for comprehensive rehabilitation in postoperative BC patients.

Integrating psychological health management and Fluorine-18 nuclear medicine nursing in cancer treatment: An innovative model for enhanced radiation protection

2025-07-04T06:50:30+00:00

Background: Fluorine-18 (F-18) nuclear medicine procedures often cause cancer patients undergoing the treatment to experience severe psychological distress, while also exposing healthcare workers to occupational radiation exposure. The study aimed to evaluate the integration of psychological health management with the Radiation-Sensitive Nursing Care Model (R-SNCM) to improve patient treatment outcomes, compliance, and healthcare worker safety. Methods: A prospective observational study was conducted at a tertiary care cancer center from January 2022 to December 2023. The study involved 236 participants, including 200 cancer patients and 36 healthcare professionals. The R-SNCM framework included patient education, emotion monitoring using the Hospital Anxiety and Depression Scale (HADS), and advanced radiation safety protocols. Outcomes were assessed through psychological scores, radiation exposure indicators, patient satisfaction, and surgical compliance. Statistical analyses were performed through paired t-tests, repeated-measures Analysis of Variance (ANOVA), and logistic regression. Results: After the intervention, the psychological distress of patients significantly decreased, with anxiety scores reducing from 10.6 ± 3.1 to 7.3 ± 2.6 and depression scores decreasing from 9.4 ± 3.5 to 6.5 ± 2.8 (p < 0.001). The monthly radiation exposure of healthcare workers was observably reduced, from 2.6 ± 0.5 mSv to 1.8 ± 0.4 mSv (p < 0.001). Patient satisfaction scores increased from 3.8 ± 0.7 to 4.6 ± 0.4 (p < 0.001), and surgical compliance improved to 95% in the intervention group compared to 81% in the control group (p < 0.001). Logistic regression indicated that attendance at training sessions (Odds Ratio (OR) = 2.85, p < 0.001) and baseline anxiety scores (β = 0.42, p < 0.001) were significant predictive factors of compliance and psychological improvement, respectively. Conclusion: The integration of psychological health management with the R-SNCM significantly improved psychological outcomes, patient compliance, and satisfaction, while reducing radiation exposure for healthcare workers. These findings support the adoption of this model as a holistic approach to cancer care.

Effects of Wu’s Long-Snake-Like Moxibustion on post-stroke cancer patients

2025-07-07T01:37:32+00:00

Background: Due to the combined effects of stroke and cancer treatment, post-stroke cancer patients face the multiple burdens of psychological distress, sleep disorders, and declined quality of life. Wu’s Long-Snake-Like Moxibustion, a therapeutic approach combining traditional Chinese medicine and modern medical concepts, aims to alleviate these challenges by regulating qi and blood through acupoint stimulation. This study explored the effects of Wu’s Long-Snake-Like Moxibustion on psychological distress, sleep disorders, and quality of life in post-stroke cancer patients, with a specific focus on hypertension as a comorbidity. Methods: A case-control study recruited 60 participants who were assigned to either the treatment group (Wu’s Long-Snake-Like Moxibustion) or the control group (standard care). Psychological distress, sleep quality, and quality of life were assessed using standardized scales, including the Hospital Anxiety and Depression Scale (HADS), Generalized Anxiety Disorder-7 (GAD-7), Pittsburgh Sleep Quality Index (PSQI), and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). Blood pressure was measured at baseline and at 12 weeks. Paired t-tests were used for intra-group comparisons, and independent t-tests were applied for inter-group differences. Results: At 12 weeks, the treatment group showed significant improvements on all measures. Anxiety (HADS-A) decreased from 14.2 (SD = 3.4) to 5.1 (SD = 2.0) (p = 0.02), and sleep quality (PSQI) improved from 8.7 (SD = 2.3) to 3.2 (SD = 1.6) (p < 0.0001). Quality of life, including physical (from 57.3 to 85.4) and emotional (from 45.8 to 80.1), significantly improved (p = 0.01 and p = 0.002, respectively). Blood pressure reductions in the treatment group were also significant, with systolic pressure dropping from 142.3 (SD = 12.5) to 118.6 (SD = 8.9) (p = 0.001). In contrast, the control group showed modest improvements in anxiety (from 13.9 to 10.4), sleep quality (from 8.3 to 6.7), and blood pressure (from 140.8 to 133.2). Conclusion: Wu’s Long-Snake-Like Moxibustion not only significantly improved the psychological distress, sleep quality, and quality of life of post-stroke cancer patients but also effectively reduced hypertension. These findings suggest that Wu’s Long-Snake-Like Moxibustion may be an effective complementary therapy for managing the complex needs of this patient population.

Improvement of anxiety in adolescent cancer patients with music therapy treatment

2025-07-10T00:42:57+00:00

Objective: This randomized controlled trial aimed to evaluate the efficacy of structured music therapy interventions in alleviating anxiety symptoms among adolescent cancer patients through dual neuroendocrine and psychological mechanisms, specifically by modulating serotonin metabolism and enhancing stress adaptation capacities. Methods: Thirty-eight adolescents (aged 12–19 years) diagnosed with cancer-related anxiety disorders were randomly assigned to either a music therapy group (n = 19) receiving biweekly 50-min sessions (24 sessions over 12 weeks) combined with standard care or a control group (n = 19) receiving standard care alone. The multimodal assessment protocol included 1) biochemical markers (serum 5-HT and salivary cortisol levels), 2) standardized psychological instruments (Beck Anxiety Inventory [BAI] and Daily Hassles Questionnaire [DHQ]), and 3) semi-structured clinical interviews. Outcome measures were collected at baseline, post-intervention, and 4-week follow-up. Results: The music therapy group demonstrated significant neuroendocrine improvements compared to controls, with a 28.6% mean increase in 5-HT levels (95% CI 18.4–38.8%, p = 0.007) and a 34.1% reduction in cortisol concentrations (95% CI 25.3–42.9%, p = 0.003) post-intervention. Psychological assessments revealed clinically meaningful reductions in BAI scores and DHQ stress frequency scores. Treatment effects remained stable at follow-up (p > 0.05 for time interaction). No significant changes were observed in control group parameters across measurement periods. Conclusion: Systematic music therapy induces durable anxiolytic effects in adolescent oncology patients through coordinated neurobiological and psychological pathways, suggesting its potential as an adjuvant therapy in pediatric psycho-oncology. The dual modulation of serotoninergic activity and hypothalamic-pituitary-adrenal axis regulation provides mechanistic insights for non-pharmacological anxiety management.

Study on comprehensive evaluation of physiological stress and mental health of lung cancer patients in emergency department and its improvement of nursing effect

2025-07-11T01:39:41+00:00

Objective: To investigate the clinical value of a dual-index comprehensive assessment of physiological stress and mental health in lung cancer patients in the emergency department, and to verify the effectiveness of comprehensive nursing interventions in improving patients’ physiological and psychological status. Methods: A single-center retrospective study was conducted, enrolling 90 lung cancer patients hospitalized in the emergency department from January 2024 to November 2024. Serum cortisol, heart rate variability (HRV, SDNN parameter), IL-6, as well as HADS, PSS, QLQ-C30 scale scores and intervention execution status were collected within 48 h of admission and 48 to 72 h after the completion of comprehensive nursing intervention. Paired t-tests were used to compare the differences in each indicator before and after the intervention, and Pearson correlation analysis was performed to explore the relationships between ΔHRV and ΔHADS, ΔPSS, and ΔQLQ-C30. Results: After the intervention, serum cortisol was significantly lower than before the intervention (P = 0.001), HRV was significantly increased (P = 0.004), and IL-6 levels were significantly reduced (P = 0.042). The HADS and PSS scores significantly decreased (both P < 0.01), while QLQ-C30 global health, emotional, and social functioning scores significantly increased (P = 0.002, 0.005, 0.021, respectively). ΔHRV was significantly negatively correlated with ΔHADS and ΔPSS (both P < 0.01) and significantly positively correlated with ΔQLQ-C30 (P < 0.01). The intervention protocol adherence was high, showing good clinical feasibility. Conclusion: Comprehensive nursing interventions can effectively reduce physiological stress levels and improve mental health and quality of life in lung cancer patients in the emergency department. Physiological and psychological indicators are closely related, and comprehensive assessment provides empirical support for individualized nursing strategies, contributing to improved clinical nursing quality and overall patient prognosis.

Effects of respiratory muscle training on psychological status and physical health of depression with sleep disorders in radiotherapy for lung cancer

2025-08-13T02:03:53+00:00

Recent years have seen a growing incidence of lung cancer (LC). This study explored the effect of respiratory muscle training (RMT) combined with vitamin B6 on patients with depression combined with sleep disorders (DSD). By comparing the Pittsburgh sleep quality index (PSQI), self-rating anxiety scale (SAS)/self-rating depression scale (SDS) of the three groups of DSD patients who received conventional rehabilitation training (n = 54), the control group who received conventional rehabilitation training combined with vitamin B6 (n = 47), and the combined group who received RMT combined with vitamin B6 (n = 65), we found that the Pittsburgh sleep quality index (PSQI), the self-rating anxiety scale (SAS)/self-rating depression scale (SDS) of the combined group were significantly lower than the PSQI. scale (SAS)/self-rating depression scale (SDS) and Clinical frailty scale (CFS) in the three groups of DSD patients, and we found that the sleep disorder, psychological status and cancer-related fatigue in the combined group were more significantly improved (P < 0.05). Meanwhile, the nutritional status of the combined group after treatment was also more favorable than the other two groups (P < 0.05). Finally, through one-year prognostic follow-up, we found that although there was no difference in prognostic survival rate and tumor recurrence rate among the three groups (P > 0.05), the Mandarin Chinese version of the Leicester Cough Questionnaire (LCQ-MC) score was higher in the combined group (P < 0.05). These results suggest that RMT combined with vitamin B6 can lay a more reliable foundation for the prognosis and rehabilitation of patients with DSD.

Psychological resilience and quality of life in lung cancer patients: A cross-sectional study in Wuhu, China

2025-08-13T02:14:52+00:00

Background: Lung cancer ranks among the most common and deadly cancers worldwide, profoundly impacting the physical, psychological, and social well-being of patients. The concept of psychological resilience—defined as the capacity to adapt and sustain mental health during challenging circumstances—has emerged as a vital element affecting the quality of life (QoL) of individuals with cancer. Objectives: This study aimed to examine whether psychological resilience is associated with quality of life in patients diagnosed with lung cancer. It specifically sought to measure resilience levels, evaluate QoL across multiple domains, and analyze the relationship between resilience and QoL using Python-facilitated statistical methods. Methods: A cross-sectional study design was utilized, involving 200 patients suffering from lung cancer who were recruited from the Wuhu City Traditional Chinese Medicine Hospital. Participants filled out the Connor-Davidson Resilience Scale (CD-RISC) to assess their psychological resilience and completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), including its lung cancer-specific module (QLQ-LC13), to evaluate their QoL. The data were analyzed through descriptive statistics, Pearson correlation coefficients, and multiple linear regression to ascertain the predictive significance of resilience on QoL while accounting for demographic and clinical factors. Results: The mean resilience score (CD-RISC) was 70.5 (SD = 12.3), and the mean overall QoL (EORTC QLQ-C30) was 65.2 (SD = 15.8). There were notable positive correlations between resilience and overall QoL (r = 0.58, p < 0.001), physical functioning (r = 0.45, p < 0.001), emotional well-being (r = 0.52, p < 0.001), and social functioning (r = 0.50, p < 0.001). Resilience also showed a negative correlation with symptom burden (r = −0.40, p < 0.001). In multiple linear regression, higher resilience remained significantly associated with better QoL (β = 0.58, p < 0.001), accounting for a substantial portion of the variability even after adjusting for age, gender, cancer stage, treatment type, and time since diagnosis. Conclusions: Higher psychological resilience was strongly associated with better QoL in lung cancer patients, including enhanced physical, emotional, and social functioning and reduced symptom burden. These findings highlight the importance of assessing and supporting resilience within clinical practice to promote comprehensive well-being among individuals undergoing lung cancer treatment. Further research—particularly with longitudinal or interventional designs—is recommended to clarify the causal pathways and optimize resilience-building strategies for diverse patient groups.

Analysis of the development trajectory and influencing factors of demoralization syndrome in young and middle-aged patients with lung cancer during chemotherapy

2025-08-14T05:50:35+00:00

Objective: This study aims to investigate the developmental trajectories and influencing factors of demoralization syndrome in young and middle-aged patients with lung cancer. Methods: From January to December 2024, 125 young and middle-aged patients with lung cancer from a tertiary Grade A hospital in Jiangxi Province were selected via convenience sampling. Data collection included the General Information Questionnaire, Demoralization Scale-II (DS-II), MD Anderson Symptom Inventory (MDASI), and Hospital Anxiety and Depression Scale (HADS). Demoralization syndrome levels were assessed at four time points: prior to the first chemotherapy, after the second chemotherapy, after the fourth chemotherapy, and after the sixth chemotherapy. Latent growth mixture modeling (LGMM) was employed to identify demoralization syndrome trajectories, while multivariate logistic regression analysis determined the factors influencing these trajectories during chemotherapy. Results: Three distinct trajectories were identified: high demoralization with fluctuating increase (27.8%), moderate demoralization with slow increase (40.3%), and low demoralization with continuous increase (36.7%). Multivariate logistic regression revealed that patient age, symptom burden, and levels of anxiety and depression significantly influenced the developmental trajectories of demoralization syndrome in these patients (P < 0.05). Conclusion: Demoralization syndrome levels in young and middle-aged patients with lung cancer undergoing chemotherapy exhibit considerable heterogeneity. Healthcare professionals should monitor variations in demoralization syndrome across patient groups and implement targeted interventions based on the identified influencing factors to mitigate demoralization.

Investigation of risk factors, PKM2 & Stat3 biomarkers, and psychological impact in high-risk HPV-positive women undergoing cervical cancer screening in outpatient clinics

2025-08-26T01:53:41+00:00

The aim of the present study was to analyze the influencing factors of cervical lesions with positive human papillomavirus (HPV) infections in women and the significance of combining pyruvate kinase M2 (PKM2) and signal transducer and activator of transcription 3 (Stat3) in cervical cancer screening. The research results are interpreted from a psychosocial perspective to provide new perspectives for the comprehensive management of cervical cancer. The study analyzed data from 149 women who underwent cervical cancer screening at The First People’s Hospital of Yuhang District, Hangzhou Hospital, between October and December 2024. Participants were tested for HPV infection using PCR-reverse dot hybridization and underwent liquid-based cytology assessment. Biomarker analysis of PKM2 and Stat3 levels in cervical secretions was performed using chemiluminescence. Statistical analyses, including logistic regression and ROC curve analysis, were conducted to evaluate risk factors for high-risk HPV infection and assess the predictive value of PKM2 and Stat3 in cervical cancer screening. In the univariate analysis, the number of sexual partners, frequency of sexual activity, frequency of condom use, reproductive tract inflammation, number of pregnancies, PKM2, and Stat3 were found to be associated with the occurrence of cervical cancer (P < 0.05). Logistic multiple regression analysis indicated that PKM2, Stat3, reproductive tract inflammation, and frequency of sexual activity had a significant impact. From a psychosocial perspective, sexual behavior-related factors are not only biological risk factors but may also have a negative impact on patients’ mental state and quality of life, such as anxiety, depression, and other emotional problems. Additionally, in receiver operating characteristic (ROC) analysis, the area under the curve (AUC) for cervical secretion screening for cervical cancer was higher than for any other single indicator (P < 0.05), providing a useful reference for clinical screening of high-risk cervical cancer populations and improving patient prognosis. The results of this study also suggest that sexual behavior-related factors may have an impact on patients’ psychology and quality of life, further emphasizing the importance of comprehensive consideration of psychosocial factors in cervical cancer screening and management.

Rehabilitation tourism enhances psychosocial health of cancer survivors in Hainan, China

2025-08-29T05:22:56+00:00

Background: Cancer survivors commonly experience considerable psychosocial burden, including anxiety, depression and low quality of life. Rehabilitation tourism—wellness, recovery travel—has been introduced as an intervention to enhance cancer survivorship with growing importance, although little research exists on how rehabilitation tourism can improve psychosocial health of cancer survivors. Methods: This paper was a mixed-method research employing narrative systematic review and semi-structured interviews to explore the effects of rehabilitation tourism on the psychosocial well-being of cancer survivors. A total of 20 survivors of breast, lung, colorectal, lymphoma and uterine cancers (n = 20) undergoing rehabilitation tourism programs in the Hainan Free Trade Port of China were interviewed. Hainan’s distinctive natural recuperation environment and pro-political policy background makes it a perfect place for considering these impacts. Conclusion: The literature review indicates that rehabilitation tourism substantially relieves anxiety and depression and enhances cancer survivors’ quality of life. And the data from qualitive interviews also indicate that being immersed in nature, making strong peer and caregiver social support and learning mindfulness-based activities on the trip could assist cancer survivors making emotional adjustment, fostering social connection and recreating sense of life meaning. They indicated a significant decrease of distress and improvements in positive expectancies and adaptation skills after tourism. Results: The literature review indicated that rehabilitation (wellness) tourism can substantially relieve anxiety and depression and enhance cancer survivors’ quality of life. Likewise, our qualitative interviews found that being immersed in nature, receiving strong peer and caregiver social support, and engaging in mindfulness-based activities during the trip helped survivors with emotional adjustment, fostered social connection, and restored a sense of life meaning. Participants overwhelmingly reported decreased distress and improved positive expectations and adaptive coping skills following the tourism experience. Conclusion: Rehabilitation wellness tourism shows promise as a novel psychosocial oncology intervention. Our findings highlight the therapeutic value of natural healing environments and supportive policy initiatives (such as those in Hainan’s Free Trade Port) in maximizing psychosocial outcomes for cancer survivors. This work offers preliminary insights into how structured wellness tourism can facilitate emotional healing and restore social functioning in cancer survivors. We recommend further research to evaluate its long-term effects and broader applicability in psycho-oncology.

Analysis of the application value and prognostic impact of comfort-oriented nursing in the operating room for gastric cancer patients with cancer-related insomnia

2025-09-03T05:23:36+00:00

Background: Cancer-related insomnia (CRI) is a prevalent and clinically significant comorbidity among patients with cancer, particularly among patients diagnosed with gastric cancer (GC). This condition not only causes erratic fluctuations in physiological parameters but also induces a series of symptoms, including fatigue, neurasthenia, and exacerbation of negative emotional states, thus disrupting the normal trajectory of treatment and hindering the recovery of patients. Objective: To evaluate the impact of comfort-oriented nursing in the operating room on the recovery outcomes of GC patients with concomitant CRI, thereby providing evidence-based insights for clinical decision-making. Methods: A total of 137 GC patients with CRI who were admitted to our institution between October 2022 and October 2023 were selected for this study. Of these patients, 72 patients who received routine nursing in the operating room composed the control group. The remaining 65 patients received comfort-oriented nursing in the operating room and composed the observation group. The postoperative gastrointestinal function recovery time was recorded in both groups. Additionally, the Pittsburgh Sleep Quality Index (PSQI) and the Self-rating Anxiety/Depression Scale (SAS/SDS) were utilized to assess sleep quality and the presence of negative emotional states, respectively. Moreover, patient postoperative pain and satisfaction with nursing care were surveyed. All the patients were followed up for 1 year, during which survival rates and quality of life metrics were documented. Results: Compared with the control group, the observation group demonstrated significantly shorter postoperative gastrointestinal function recovery times (P < 0.05). Additionally, patients in the observation group had lower PSQI, SAS, and SDS scores after the intervention (P < 0.05). Moreover, patients in the observation group reported milder postoperative pain and higher satisfaction with nursing care (P < 0.05). Finally, although no significant intergroup differences were observed in overall survival rates during the 1-year follow-up period (P > 0.05), patients in the observation group reported better quality of life. Conclusion: comfort-oriented nursing in the operating room can effectively ameliorate sleep disturbances and mitigate negative emotions in GC patients with CRI, thereby facilitating the postoperative recovery of these patients.

A study of distance learning technology in psychological support groups for cancer patients

2025-09-04T03:30:23+00:00

Mental health issues have become increasingly prominent in the treatment of cancer patients and have become an important factor affecting their outcome and quality of life. In recent years, a number of studies have revealed the psychological challenges faced by cancer patients, pointing out that psychological problems such as anxiety and depression are common among cancer patients, and that these problems not only diminish the patients' quality of life, but may also affect treatment adherence and treatment efficacy. Although traditional psychological support methods, such as face-to-face counselling, can alleviate patients ‘psychological pressure to a certain extent, their coverage and accessibility are limited by factors such as patients’ physical conditions, remote living places and inconvenient transportation. Therefore, how to innovate the service mode and expand the coverage of psychological support has become an urgent problem. This study aims to explore the effectiveness of distance learning technology in psychological support groups for cancer patients, with a view to providing new ideas and practical solutions for future mental health interventions.

Correlation between sleep quality and adverse reactions to chemotherapy, mental health status and quality of life in breast cancer patients undergoing chemotherapy

2025-09-09T06:03:48+00:00

Objective: To analyze the correlation between sleep quality and adverse reactions to chemotherapy, mental health status, and quality of life in breast cancer patients undergoing chemotherapy. Methods: Two hundred and seventy-one eligible breast cancer patients undergoing chemotherapy in the Cancer Hospital of the Chinese Academy of Medical Sciences from January 2023 to December 2023 were selected as the study objects. Patients were assessed using the General Information Questionnaire, the Pittsburgh Sleep Quality Index (PSQI) scale, the Symptom Checklist 90 (SCL-90), the Symptom Measurement scale, and the Functional Assessment of Cancer Therapy-Breast (FACT-B) scale. Spearman correlation analysis was used to measure the correlation between sleep quality and adverse reactions to chemotherapy, mental health status, and quality of life in breast cancer patients undergoing chemotherapy. Results: The total incidence of grade I/II/III/IV adverse reactions in the sleep disorder group was higher compared to the normal sleep group (all P < 0.05). The sleep quality of patients with mild adverse reactions was better compared to patients with severe adverse reactions (all P < 0.05). The degree of adverse reactions was positively linked to the total PSQI score (r = 0.531, P < 0.001). The total PSQI score was positively correlated with the total SCL-90 score after chemotherapy, indicating that the worse the sleep quality was, the worse the mental health status of patients (r = 0.513, P < 0.001). The degree of adverse reactions to chemotherapy was positively correlated with the total SCL-90 score (r = 0.542, P < 0.001). After chemotherapy, the total FACT-B score and each status score in patients with sleep disorder were significantly lower compared to normal sleep patients (all P < 0.05). The total PSQI score was negatively correlated with the total FACT-B score after chemotherapy (r = −0.679, P < 0.001). The degree of adverse reactions to chemotherapy was negatively correlated with the total FACT-B score (r = −0.762, P < 0.001). The total SCL-90 score was negatively correlated with the total FACT-B score (r = −0.567, P < 0.001). Conclusion: Sleep disorders are common in breast cancer patients undergoing chemotherapy, which interacts with the degree of adverse reactions to chemotherapy, mental health, and quality of life.

Effects of comprehensive psychosocial intervention on intervention effect and quality of life of cancer patients

2025-09-09T06:23:06+00:00

Objective: Cancer patients often face strong negative emotions such as anxiety and depression. Long-term experience and psychological stress may lead to emotionally unstable personality disorder in cancer patients, which is characterized by large mood swings, easy agitation, difficulty in controlling emotions, dependent personality disorder, and excessive dependence on the care and support of others. Our study explored the effects of comprehensive psychosocial intervention on intervention outcomes and quality of life in cancer patients.

Methods: A total of 120 cancer patients who received chemotherapy for colorectal cancer in our hospital from June 2022 to December 2023 were selected as subjects, and were divided into control group and observation group with 60 groups in each group according to random number table method. The control group received routine nursing intervention, and the observation group was combined with comprehensive social psychological intervention on the basis of the control group. The changes of cancer-related fatigue, cancer symptoms, perceived stress, self-efficacy and quality of life before and after intervention were compared between the two groups.

Result: In our study, after 6 months of intervention, the scores of cancer-related Fatigue Scale (CFS), Anderson Symptom Scale (MDASI) and Chinese version of Stress Perception Scale (CPSS) in both groups decreased in all dimensions, the observation group was lower than the control group (P<0.05), and the scores of GSES and EORTC QLQ-C30 in both groups increased. The observation group was higher than the control group (P<0.05).

Conclusion: Our study found that comprehensive psychosocial intervention can alleviate cancer symptoms, fatigue, reduce perceived stress, improve quality of life, and enhance self-efficacy in cancer patients.

Harnessing Sorority for Breast Cancer Support: The INEN ‘Club de la Mama’ Experience in Peru

2025-09-09T06:47:36+00:00

Objective: To explore how sorority is expressed among women with breast cancer participating in the “Club de la Mama” (Breast Club) support group at the National Institute of Neoplastic Diseases (INEN), Peru, through an analysis of their experiences, perceptions, and the perceived impact of the group on their illness journey. Materials and methods: A qualitative phenomenological study was conducted with a purposive sample of 56 women diagnosed with breast cancer who were active participants in the “Club de la Mama”. Data were collected through semi-structured interviews and focus groups. Thematic analysis was carried out using ATLAS.ti 8 software. Results: Four key dimensions of sorority were identified among participants. First, emotional support and self-esteem emerged as a central theme, with the group providing a safe space for emotional expression that helped reduce anxiety and depression. Second, trust and support network building was evident through strengthened interpersonal bonds and a growing sense of mutual reliance within the group. Third, mutual care and joint learning highlighted the importance of exchanging knowledge about the disease and coping strategies, fostering collective resilience. Finally, participants expressed a strong appreciation for unity and shared vulnerability, recognizing the power of solidarity in navigating their illness together. Conclusions: Sorority plays a fundamental role in the lived experience of women with breast cancer, promoting emotional well-being, strengthening support networks, and enhancing personal empowerment. The integration of such peer support spaces within the healthcare system has the potential to improve patients’ quality of life and contribute to better adherence to treatment.

Three predictive models for fear of cancer recurrence among recovering breast cancer patients

2025-09-15T05:23:34+00:00

Objectives: Fear of cancer recurrence (FCR) is a common psychological issue among breast cancer patients, yet predictive methods are lacking. This study aimed to construct and compare three models for predicting FCR among recovering breast cancer patients. Methods: A total of 490 breast cancer patients in rehabilitation were recruited from a university hospital in Harbin, China. Factors affecting FCR were collected using specific questionnaires. Multivariate analysis identified effective influencing factors, which were used as independent variables in a logistic regression model, an artificial neural network (ANN) model, and a random forest model. The dependent variable was high-level FCR. Models were validated using 10 × 10 cross-validation, and their performance was compared using AUC values, sensitivity, specificity, accuracy, positive predictive value, and negative predictive value. Results: Six factors influenced FCR: age, occupational status, chemotherapy, self-image, cancer-caused fatigue, and disease perception. The logistic regression model showed an accuracy of 83.7%, sensitivity of 79.3%, specificity of 86.9%, positive predictive value of 85.1%, negative predictive value of 81.7%, and an AUC value of 0.746. The ANN model had an accuracy of 78.2%, sensitivity of 80.0%, specificity of 75.8%, positive predictive value of 81.9%, negative predictive value of 73.4%, and an AUC value of 0.746. The random forest model demonstrated an accuracy of 84.4%, sensitivity of 89.4%, specificity of 77.4%, positive predictive value of 84.4%, negative predictive value of 84.2%, and an AUC value of 0.892. Conclusion: The random forest model outperformed the ANN and logistic regression models in predicting FCR in recovering breast cancer patients, making it a valuable tool for screening high-risk FCR groups during rehabilitation.

The effects of training program on distress levels among women breast cancer patients

2025-09-18T06:36:35+00:00

Objective: Women with breast cancer experience significant distress during the diagnosis and treatment process. This study was conducted quasi-experimentally to evaluate the effects of an individual training program given to women with breast cancer on distress. Methods: It was carried out in a university hospital with patients who were diagnosed with breast cancer and admitted to the General Surgery Clinic to be operated on. The study was completed with a total of 73 patients (the experimental group with 37 patients and the control group with 36 patients). Data for the study were collected through a personal information form and a distress thermometer. Results: It was found that both groups continued to experience more than four severe distress episodes on the tenth day, first month, and third month with a cancer diagnosis, after surgery. Conclusion: Nurses can provide individual training and counseling to women with breast cancer according to their individual needs, so that they can better manage the distress experienced during the treatment process.

Problems of psychological assistance to patients with neurofibromatosis type I

2025-07-03T00:47:39+00:00

Neurofibromatosis type I is one of the most common hereditary tumor syndromes and is characterized by the development of multiple skin and subcutaneous tumors on the body, disfiguring the appearance of patients. The literature search strategy on psychological care for patients with neurofibromatosis type I included searching for relevant articles in Scopus, Web of Science, and PubMed. Half of patients with neurofibromatosis type I develop plexiform neurofibromas, which can compress internal organs, deform the face or limbs, and impair self-care and social adaptation. Surgical methods are used to treat cutaneous and subcutaneous neurofibromas, but the number of these tumors is increasing, causing serious psychological trauma to patients. In this regard, common problems of patients with neurofibromatosis type I, in addition to tumor damage, are psychological disorders such as anxiety, depression, and distress. These disorders worsen the quality of life of patients and require qualified psychological assistance. This article examines the nature and frequency of psychological disorders in patients with neurofibromatosis type I, as well as problems associated with the availability of psychological assistance. Measures are proposed for the timely identification of distress, anxiety and depression in patients and their treatment with routing for consultations with the necessary specialists. An analysis of the scientific literature shows a lack of publications in the field of research into the psychological problems of patients with neurofibromatosis type I compared to cancer patients. Future directions of research in this area should involve active involvement of department staff, psychotherapists and psychologists in the examination of patients with neurofibromatosis type I throughout the world.

Effects of a computer-based applications intervention on anxiety, depression and quality of life among lung cancer patients: A systematic review and meta‑analysis

2025-07-03T06:17:06+00:00

Objectives: Lung cancer is associated with higher anxiety and depression than other cancers, accelerating the deterioration of the quality of life (QoL). There is a limited comprehensive evaluation about computer-based intervention (CBI) which uses technological approaches to manage these issues. This meta-analysis sought to evaluate the efficacy of CBI in mitigating anxiety and depression while enhancing quality of life among lung cancer patients. Methods: This systematic review and meta-analysis were conducted following PRISMA guidelines; it has been registered with PROSPERO (CRD42023397575). Randomized controlled trials (RCTs) published up to 31 December 2024 were searched from PubMed, Cochrane Library, and the Embase database. The primary outcomes assessed were quality of life, anxiety, and depression. The results are presented as standardized mean differences (SMD) with a 95% confidence interval. Results: A total of 3018 patients were included in 12 randomized controlled trials. The primary outcome of this meta-analysis demonstrated a statistically significant difference between CBI and usual care, significantly improved QoL (SMD = 3.92, 95% CI: 2.36 to 5.47, p < 0.00001, I² = 97%), anxiety (SMD: −0.63, 95% CI: −1.04 to 0.22, p = 0.002, I² = 79%) and depression (SMD: −0.47, 95% CI: −0.57 to −0.36, p < 0.00001, I² = 0%). Conclusions: Computer-based applications intervention has been demonstrated to significantly reduce anxiety and depression and improve QoL among lung cancer patients.

Exercise as a therapeutic intervention: A comprehensive review of the psychological benefits in cancer survivors

2025-07-14T01:49:46+00:00

Cancer is a crucial global health concern, as it is interrelated with many life-threatening diseases. The number of cancer victims who have lived through this ordeal has considerably grown through early cancer detection and treatment. The objective of this paper is to conduct a full amplitude assessment on the problem of how to use exercise as a non-pharmacological therapeutic intervention for cancer patients. This study is to summarize and scrutinize the recent research results so as to provide a definitive theory and apply it to practice, including the modified practical guidelines. Within this framework, this review puts forward the idea that sports, can provide a novel therapeutic pathway for psychological rehabilitation in people by promoting emotional well-being, through the new lens of improving quality of life and self-efficacy, and alongside the other multifaceted psychological benefits of the process. Not only does this article provide a new light to the psychological benefits of exercise interventions, including reaching out to the issues of intervention protocols’ optimization, long-term effects’ assessment, and exercise’s integration with other therapeutic modalities, but it also emphasizes that by refining existing studies, these aspects can be worked on.

Research progress of psychological intervention assisted gold nanoparticles drug delivery in the treatment of triple-negative breast cancer patients

2025-08-26T01:43:20+00:00

Objective: Breast cancer represents the most prevalent malignant tumor among women worldwide. Among the subtypes of breast cancer, triple-negative breast cancer (TNBC) exhibits the highest rates of recurrence and mortality. Early diagnosis and effective treatment play a crucial role in delaying the progression of TNBC, prolonging patient survival, and enhancing the quality of life. Therapeutic strategies that leverage gold nanoparticles for targeted drug delivery show significant potential in improving outcomes for patients with TNBC, and adjuvant therapy with early psychological intervention for patients has also attracted much attention. This paper reviews the current advancements in the application of psychological intervention combined with gold nanoparticles in targeted drug delivery and treatment strategies for TNBC, providing a theoretical framework for their clinical application in managing this aggressive breast cancer subtype. Methods: Literature in this article was obtained primarily by searching the PubMed database. We used keywords to search articles: breast cancer, triple-negative breast cancer, nanoparticles, gold nanoparticles, drug delivery, psychological intervention, drug therapy. Results: We found that targeted drug delivery with gold nanoparticles was significantly effective in the treatment of TNBC patients, but psychological intervention assisted targeted drug delivery with gold nanoparticles was significant for improving the survival time and quality of life of patients. Conclusion: Therapeutic strategies for targeted drug delivery with gold nanoparticles are increasing and technology is becoming more and more mature. Targeted drug delivery with gold nanoparticles combined with psychological intervention can effectively delay the process of disease development while improving the survival beliefs of patients with TNBC.

Mindfulness-based physical activity for mental health and resilience in cancer patients: A systematic review and network meta-analysis

2025-09-15T02:42:52+00:00

This systematic review and network meta-analysis examined the comparative effectiveness of mindfulness-based physical activity interventions on psychological outcomes in cancer patients. Following PRISMA-NMA guidelines, we searched 12 databases from inception to December 2023, identifying 30 randomized controlled trials (3518 participants) that met inclusion criteria. The network meta-analysis revealed significant benefits across psychological domains, with differential effectiveness among intervention modalities. Mindfulness-Based Stress Reduction (MBSR) demonstrated superior efficacy for anxiety (SMD = −0.45, 95% CrI: −0.59 to −0.31) and depression (SMD = −0.41, 95% CrI: −0.55 to −0.27), while mindful walking yielded optimal improvements for quality of life (SMD = 0.52, 95% CrI: 0.36 to 0.68). Subgroup analyses identified cancer type, treatment stage, and intervention format as significant moderators of effectiveness, with stronger effects observed during active treatment compared to post-treatment periods. Medium-duration interventions (8–12 weeks) delivered in supervised group formats showed optimal outcomes. Network inconsistency was minimal (global inconsistency factor: 0.11, p = 0.42), and publication bias assessment suggested no significant bias. Our findings provide robust evidence supporting the integration of mindfulness-based physical activity interventions into cancer care, with MBSR recommended for addressing anxiety and depression, and mindful walking for enhancing quality of life. These findings highlight the importance of tailoring intervention selection to specific psychological outcomes and patient characteristics, potentially improving psychological resilience throughout the cancer journey.

A study of the impact of psychological interventions in the application of nursing care to neurosurgical oncology patients: A systematic review

2025-09-15T05:30:06+00:00

Neurosurgical oncology patients face substantial psychological and cognitive burdens that complicate recovery and diminish quality of life. Nurses, through their continuous presence, are uniquely positioned to deliver psychological interventions that alleviate these challenges. This systematic review, conducted in line with PRISMA 2020, synthesized 20 studies published between 2010 and 2025 examining nurse-led psychological interventions, including cognitive-behavioural therapy, mindfulness, psychoeducation, supportive counselling, relaxation training, and multimodal approaches—in adults with brain tumours. Findings consistently demonstrated reductions in anxiety and depression, enhanced coping, resilience, and quality of life, and, in several cases, improvements in adherence, pain management, and hospital length of stay. Mechanisms of benefit included strengthened coping strategies, therapeutic alliance, and self-efficacy, while effects were moderated by patient characteristics, intervention design, and healthcare context. Interventions targeting cognitive decline, such as goal management training and digital rehabilitation tools, showed promise but were constrained by small samples and short follow-up. Despite methodological heterogeneity, the evidence supports embedding psychological interventions into nursing practice as a feasible, effective, and ethically essential component of neurosurgical oncology care. Future priorities include larger multicentre trials with standardized outcomes, extended follow-up, and evaluation of cultural and economic factors to guide implementation and ensure equitable access to psychosocial support.

Systematic evaluation and meta-analysis of Herceptin® (trastuzumab) in the treatment and care of breast cancer

2025-09-16T06:37:24+00:00

Breast cancer remains the most prevalent malignancy among women worldwide and poses both biomedical and psychosocial challenges. Trastuzumab (Herceptin^®), a monoclonal antibody targeting the HER2 receptor, has transformed the prognosis of patients with HER2-positive disease. This systematic review and meta-analysis synthesized data from 19 eligible studies including 9735 patients to evaluate trastuzumab’s efficacy, safety, and implications for patient care. The pooled analysis demonstrated significant improvements in overall survival, disease-free survival, progression-free survival, and overall response rate compared with standard therapy, with hazard ratios consistently favoring trastuzumab. Most adverse effects were mild to moderate, though cardiac toxicity remains a critical concern requiring vigilant monitoring. Beyond these biomedical outcomes, the findings carry important psycho-oncological implications: improved survival helps reduce fear of recurrence and psychological distress, while manageable toxicity and supportive nursing care enhance treatment adherence and quality of life. These results underscore trastuzumab’s dual role as both a therapeutic cornerstone and a psychosocially meaningful intervention. Future research should integrate patient-reported outcomes, resilience measures, and cost-effectiveness analyses to ensure that survival benefits translate into comprehensive improvements in the lived experiences of patients with breast cancer. Such integration will help position trastuzumab not only as a biomedical intervention but also as a psycho-oncological strategy to support holistic survivorship.

The intervention mechanisms of square dance exercise participation on loneliness and social alienation in elderly cancer patients: A systematic review

2025-09-17T09:32:11+00:00

Loneliness and social alienation are key psychosocial challenges in the integrated care of elderly cancer patients, significantly affecting their quality of life and treatment outcomes. This systematic review integrates two decades of interdisciplinary research and uses bibliometric analysis to elucidate the multidimensional mechanisms behind square dance exercise (SDE) as an effective nonpharmacological intervention. Empirical research shows that the mechanism of action of SDE involves three synergistic pathways: rebuilding social support networks, regulating neuroendocrine responses, and achieving behavioral cognitive reconstruction through group action synchronization. Studies have confirmed that moderating factors such as cultural-community embeddedness, collective action coordination, and disease stage adaptability have a significant impact on the intervention effect. The proposed “exercise-neuroplasticity-social synergy” (ENSS) framework emphasizes that combining open community spaces with culturally familiar movement patterns can effectively reduce implementation barriers in resource-limited settings. The inherent accessibility, low cost, and lifestyle embeddedness of SDE establish a scalable model for psycho-oncology rehabilitation in the aging population. Future study should focus on developing intervention protocols that are adapted to different cultures and optimized for dose-response, as well as establishing dynamic assessment models using neurobehavioral biomarkers to promote a paradigm shift from empirical approaches to precision personalized interventions. This eco-centric intervention paradigm, based on community-engaged behavioral neuroscience, provides a transformative, interdisciplinary research approach to alleviate psychosocial distress in elderly cancer patients.