Effects of a psychoneurointeraction-based personalized psychological care model on postoperative recovery in glioblastoma patients
Abstract
Background: Glioblastoma (GBM) is a common malignant neuroepithelial tumor of the central nervous system in adults. The preferred treatment method is surgical treatment. During the perioperative period, patients will experience huge physiological and psychological burdens, which may influence the surgical outcome and recovery. Traditional nursing care patterns lack individualized psychological intervention and show limited impact on patients’ psychological states. Objective: This study seeks to investigate the effects of individualized psychological nursing care on the psychological states, neuroendocrine responses, and postoperative recovery for patients with GBMs in the perioperative period. Methods: This was a prospective quasi-experimental study conducted at the Affiliated Hospital of Yanbian University from January 2023 to March 2024. A total of 84 GBM patients undergoing surgical treatment were enrolled and assigned into a treatment group (n = 42) and a control group (n = 42) using 1:1 propensity score matching. The treatment group received a personalized psychological care model based on psychoneurointeraction theory in addition to standard nursing care, while the control group received standard psychological nursing care only. Evaluations were conducted 1 day preoperatively, and on postoperative Days 3 and 7. Primary outcomes included psychological measures (anxiety, depression, perceived stress) and physiological markers [serum cortisol, 5-hydroxytryptamine (5-HT), dopamine, and inflammatory markers]. Results: The treatment group displayed substantially lowered scores for anxiety, depression, and perceived stress on Days 3 and 7 postoperatively compared with those in the control group (P < 0.05); this group also showed remarkably lowered levels of serum cortisol and inflammatory factors [interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)] in contrast with the control group (P < 0.05). Conclusion: The intervention method of individualized psychological nursing care based on the theory of neural interactions can bring about dramatic improvements for GBM patients’ perioperative mental states, physiological stress responses, postoperative recovery, and complications.
Copyright (c) 2025 Jiayang Xu, Aiping Xu, Jia Yu, Longfan Piao
This work is licensed under a Creative Commons Attribution 4.0 International License.
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