Harmonizing healing: A meta-analysis of music therapy’s role in cancer patient mental health and psychological resilience
Abstract
Background: The therapeutic potential of music therapy, a non-invasive, affordable, and adaptable psychosocial intervention, has gained increasing attention in cancer care. Cancer diagnosis and treatment are often accompanied by significant psychological challenges, including anxiety, depression, emotional distress, and fatigue, all of which can substantially reduce patients’ quality of life (QoL). Addressing these psychological issues is essential for delivering comprehensive, holistic care. Existing studies vary in terms of therapy types, delivery methods, treatment phases, and patient populations. This heterogeneity can affect the comparability of findings and limit the generalizability of individual study outcomes. Aim: The aim of this study is to conduct a comprehensive meta-analysis to assess the impact of music therapy on the psychological well-being and resilience of cancer patients. Method: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic selection of peer-reviewed studies was conducted based on inclusion criteria such as study design, participant characteristics, type of music intervention, and measurable psychological outcomes. Both active (e.g., singing, playing instruments, songwriting) and receptive (e.g., listening to live or recorded music) forms of therapy were considered across various types and stages of cancer. Results: The findings demonstrated statistically significant improvements in emotional health, reduced symptoms of anxiety and depression, and increased coping ability (Hedges’ g = 0.51; 95% CI: 0.36 to 0.66; p < 0.001) and psychological resilience (Hedges’ g = 0.47; 95% CI: 0.33 to 0.61; p < 0.001). Effectiveness and heterogeneity among mental results in cancer patients were assessed using statistical analysis utilising meta-analysis with random-effects models. Conclusion: Interventions conducted by certified music therapists, particularly when initiated early in treatment, were particularly more effective. Music therapy is an effective complementary treatment in cancer care. Its integration into supportive care frameworks is recommended to enhance psychological recovery, emotional strength, and overall well-being in cancer patients.
Copyright (c) 2026 Junyan Wang, Junzhu Zhao

This work is licensed under a Creative Commons Attribution 4.0 International License.
References
1. Eseadi C, Ngwu MO. Significance of music therapy in treating depression and anxiety disorders among people with cancer. World Journal of Clinical Oncology. 2023; 14(2): 69–80. doi: 10.5306/wjco.v14.i2.69
2. Fortin J, Leblanc M, Elgbeili G, et al. The mental health impacts of receiving a breast cancer diagnosis: A meta-analysis. British Journal of Cancer. 2021; 125(11): 1582–1592. doi: 10.1038/s41416-021-01542-3
3. Rosenheck M, Hirsh R. Quantitative and qualitative effects of live music medicine on anxiety and depression in cancer inpatients. 2022; doi: 10.1101/2022.10.19.22281272
4. De Feudis RL, Graziano G, Lanciano T, et al. An art therapy group intervention for cancer patients to counter distress before chemotherapy. Arts & Health. 2019; 13(1): 35–48. doi: 10.1080/17533015.2019.1608566
5. Knoerl R, Mazzola E, Woods H, et al. Exploring the Feasibility of a Mindfulness-Music Therapy Intervention to Improve Anxiety and Stress in Adolescents and Young Adults with Cancer. Journal of Pain and Symptom Management. 2022; 63(4): e357–e363. doi: 10.1016/j.jpainsymman.2021.11.013
6. Chang TW, Tsai ST, Huang HY, et al. Slow Well-Being Gardening: Creating a Sensor Network for Radiation Therapy Patients via Horticultural Therapeutic Activity. Sensors. 2024; 24(12): 3771. doi: 10.3390/s24123771
7. Kobus S, Diezel M, Dewan MV, et al. Music therapy in preterm infants reduces maternal distress. International Journal of Environmental Research and Public Health. 2022; 20(1): 731. doi: 10.3390/ijerph20010731
8. Ferro MM, Pegueroles AF, Lorenzo RF, et al. The effect of a live music therapy intervention on critically ill paediatric patients in the intensive care unit: A quasi-experimental pretest–posttest study. Aust Crit Care. 2023; 36(6): 967–73. doi: 10.1016/j.aucc.2023.01.006
9. Liu Y, Bi K, Hodges S, et al. Harmonious Healing: Advances in Music Therapy and other Alternative Therapy for Depression and Beyond. Brain Behavior and Immunity Integrative. 2024; 8: 100094. doi: 10.1016/j.bbii.2024.100094
10. Zeppegno P, Krengli M, Ferrante D, et al. Psychotherapy with Music Intervention Improves Anxiety, Depression and the Redox Status in Breast Cancer Patients Undergoing Radiotherapy: A Randomized Controlled Clinical Trial. Cancers. 2021; 13(8): 1752. doi: 10.3390/cancers13081752
11. Xie J, Wan Z, Duan Y, et al. The efficacy of live music for adolescent and young adult patients during hematopoietic stem cell transplantation. Supportive Care in Cancer. 2022; 30(7): 5789–5799. doi: 10.1007/s00520-022-07001-w
12. Wang Z, Deng S, Lv H, et al. Effect of WeChat‐based continuous care intervention on the somatic function, depression, anxiety, social function and cognitive function for cancer patients: Meta‐analysis of 18 RCTs. Nursing Open. 2023; 10(9): 6045–6057. doi: 10.1002/nop2.1916
13. Xu M, Zhou L, Zheng L, et al. Sonodynamic therapy-derived multimodal synergistic cancer therapy. Cancer Letters. 2021; 497: 229–242. doi: 10.1016/j.canlet.2020.10.037
14. Salimi M, Mosca S, Gardner B, et al. Nanoparticle-Mediated Photothermal Therapy Limitation in Clinical Applications Regarding Pain Management. Nanomaterials. 2022; 12(6): 922. doi: 10.3390/nano12060922
15. Giordano F, Rutigliano C, Baroni M, et al. Music therapy and pediatric palliative care: songwriting with children in the end-of-life. World Journal of Pediatrics. 2022; 18(10): 695–699. doi: 10.1007/s12519-022-00578-6
16. Lin C, Diao Y, Dong Z, et al. The effect of attention and interpretation therapy on psychological resilience, cancer-related fatigue, and negative emotions of patients after colon cancer surgery. Annals of Palliative Medicine. 2020; 9(5): 3261–3270. doi: 10.21037/apm-20-1370
17. Zhang J, Xu X, Wang Z, et al. The effects of cognitive bias modification for attention and interpretation on the postoperative psychological resilience and quality of life of patients with pituitary adenoma: a randomized trial. Annals of Palliative Medicine. 2021; 10(5): 5729–5737. doi: 10.21037/apm-21-782
18. Zhang Y, Tang R, Bi L, et al. Effects of family-centered positive psychological intervention on psychological health and quality of life in patients with breast cancer and their caregivers. Supportive Care in Cancer. 2023; 31(10). doi: 10.1007/s00520-023-08053-2
19. Li Q, Zhang L, Chen C, et al. Caregiver burden and influencing factors among family caregivers of patients with glioma: A cross-sectional survey. Journal of Clinical Neuroscience. 2022; 96: 107–113. doi: 10.1016/j.jocn.2021.11.012
20. Zhang A, Wang K, Blumenstein K, et al. For whom and what outcomes does cognitive-behavioral-therapy work among cancer survivors: a systematic review and meta-analysis. Supportive Care in Cancer. 2022; 30(11): 8625–8636. doi: 10.1007/s00520-022-07337-3
21. Mahdavi A, Sobhani ZR. Spiritual therapy’s impact on death anxiety in Iran: A systematic review and meta-analysis. Archive for the Psychology of Religion. 2024; 47(3): 330–344. doi: 10.1177/00846724241295779
22. Laux CM, Elagami RA, Santos A dos, et al. Risk of Bias and Methodological Critical Appraisal in Systematic Reviews of Non- and Micro-Invasive Caries Management for Primary and Permanent Teeth. Caries Research. 2024; 58(5): 469–477. doi: 10.1159/000537749
23. Maus E, Scott K, Ferrante R, et al. Monitoring Treatment Fidelity in a Pragmatic Pediatric Rehabilitation Trial Comparing Two Physical Therapy Schedules: Analysis and Unexpected Findings. Physical Therapy. 2025; 105(3). doi: 10.1093/ptj/pzaf004
24. D’Souza AN, Peiris CL, Darzins S, et al. Fidelity, acceptability, and feasibility of the revised functional autonomy measurement system for hospitalised people: An implementation study. Australian Occupational Therapy Journal. 2024; 72(2). doi: 10.1111/1440-1630.13006
25. Green SMC, Graham CD, Collinson M, et al. Assessing multidimensional fidelity in a pilot optimization trial: A process evaluation of four intervention components supporting medication adherence in women with breast cancer. Translational Behavioral Medicine. 2024; 15(1). doi: 10.1093/tbm/ibae066
26. Biener SN, L. Høeg B, Saltbæk L, et al. Fidelity of the Guided Self-Determination program in the MyHealth study during breast cancer follow-up. Acta Oncologica. 2025; 64: 284–291. doi: 10.2340/1651-226x.2025.42253
27. Wernhart S, Rassaf T. Relevance of Cardiovascular Exercise in Cancer and Cancer Therapy-Related Cardiac Dysfunction. Current Heart Failure Reports. 2024; 21(3): 238–251. doi: 10.1007/s11897-024-00662-0
28. Chiavarini M, Rosignoli P, Sorbara B, et al. Benzene Exposure and Lung Cancer Risk: A Systematic Review and Meta-Analysis of Human Studies. International Journal of Environmental Research and Public Health. 2024; 21(2): 205. doi: 10.3390/ijerph21020205
29. Chang CJ, Ish JL, Chang VC, et al. Exposure to per- and polyfluoroalkyl substances and breast cancer risk: a systematic review and meta-analysis of epidemiologic studies. American Journal of Epidemiology. 2024; 193(8): 1182–1196. doi: 10.1093/aje/kwae010
30. Ye M, Shou M, Zhang J, et al. Efficacy of cognitive therapy and behavior therapy for menopausal symptoms: a systematic review and meta-analysis. Psychological Medicine. 2022; 52(3): 433–445. doi: 10.1017/s0033291721005407
31. Ciharova M, Karyotaki E, Miguel C, et al. Amount and frequency of psychotherapy as predictors of treatment outcome for adult depression: A meta-regression analysis. Journal of Affective Disorders. 2024; 359: 92–99. doi: 10.1016/j.jad.2024.05.070
32. Janitra FE, Chen R, Lin H, et al. Efficacy of resilience‐related psychological interventions in patients with long‐term diseases: A meta‐analysis of randomised controlled trials. International Journal of Mental Health Nursing. 2024; 33(5): 1388–1406. doi: 10.1111/inm.13334
33. Broström A, Alimoradi Z, Odzakovic E, et al. Quality of life among patients with restless legs syndrome: A systematic review and meta-analysis. Journal of Clinical Neuroscience. 2024; 122: 80–91. doi: 10.1016/j.jocn.2024.02.027
34. Liu Y, Lee DH, Kosowicz E, et al. Targeting mental health: A scoping review of acupoints selection in acupressure for depression, anxiety, and stress. Brain Behavior and Immunity Integrative. 2025; 10: 100111. doi: 10.1016/j.bbii.2025.100111
35. Feng Y, Wang M. Effect of music therapy on emotional resilience, well-being, and employability: a quantitative investigation of mediation and moderation. BMC Psychology. 2025; 13(1). doi: 10.1186/s40359-024-02336-x
36. Xiang L, Wan H, Zhu Y. Effects of cognitive behavioral therapy on resilience among adult cancer patients: a systematic review and meta-analysis. BMC Psychiatry. 2025; 25(1). doi: 10.1186/s12888-025-06628-3
37. Reyes Aragón L, Díaz AM, Suárez R, et al. Effect of a Single Live Group Music Therapy Intervention on Anxiety-State and Well-Being Levels During Chemotherapy: A Multicenter Randomized Clinical Trial Protocol. Global Advances in Integrative Medicine and Health. 2024; 13. doi: 10.1177/2753613024131024
38. Molendijk-van Nieuwenhuyzen K, Belt-van Opstal R, Hakvoort L, et al. Exploring geriatric trauma unit experiences through patients’ eyes: a qualitative study. BMC Geriatrics. 2024; 24(1). doi: 10.1186/s12877-024-05023-z
39. Salgado-Vasco A, Torres-Morales J, Durán-Rojas CI, et al. The impact of group music therapy on anxiety, stress, and wellbeing levels, and chemotherapy-induced side effects for oncology patients and their caregivers during chemotherapy: a retrospective cohort study. BMC Complementary Medicine and Therapies. 2025; 25(1). doi: 10.1186/s12906-025-04837-7
40. Giordano F, Rutigliano C, Ugolini C, et al. Effect of Music Therapy on Chemotherapy Anticipatory Symptoms in Adolescents: A Mixed Methods Study. Journal of Pain and Symptom Management. 2024; 68(1): e62–e74. doi: 10.1016/j.jpainsymman.2024.04.019
41. Nguyen KT, Hoang HTX, Bui QV, et al. Effects of music intervention combined with progressive muscle relaxation on anxiety, depression, stress and quality of life among women with cancer receiving chemotherapy: A pilot randomized controlled trial. Clemence M, ed. Plos One. 2023; 18(11): e0293060. doi: 10.1371/journal.pone.0293060
42. Sheikh-Wu SF, Kauffman MA, Anglade D, et al. Effectiveness of different music interventions on managing symptoms in cancer survivors: A meta-analysis. European Journal of Oncology Nursing. 2021; 52: 101968. doi: 10.1016/j.ejon.2021.101968
43. Lehrer P, Kaur K, Sharma A, et al. Heart Rate Variability Biofeedback Improves Emotional and Physical Health and Performance: A Systematic Review and Meta Analysis. Applied Psychophysiology and Biofeedback. 2020; 45(3): 109–129. doi: 10.1007/s10484-020-09466-z
44. Taghvaeinia A, Karami M, Azizi A. Comparison of the Effect of Dialectical Behavior Therapy, Acceptance and Commitment Therapy mindfulness-based Stress Reduction on Irritable Bowel Syndrome Symptoms, Quality of Life, Anxiety and Depression: A Pilot Randomized Controlled Trial. Psychiatric Quarterly. 2023; 95(1): 53–68. doi: 10.1007/s11126-023-10058-3
45. Lázaro-García A, Láinez-González D, González-Rodríguez M, et al. Music Listening in Stem Cell Transplantation and Acute Myeloid Leukemia: A Randomized Clinical Trial. Journal of Pain and Symptom Management. 2024; 67(6): 501–511.e12. doi: 10.1016/j.jpainsymman.2024.02.567
46. Stewart SR. Integrating improvisation with patient preferred music in adult medical music therapy [PHD thesis]. Drexel University; 2024. doi: 10.17918/00002028
47. Menza R, Bongiovanni T, Leutwyler H, et al. Music-Based Interventions for Symptom Management in Critically Ill, Mechanically Ventilated Adults: A Scoping Review of the Literature. Journal of Integrative and Complementary Medicine. 2024; 30(11): 1047–1071. doi: 10.1089/jicm.2023.0483
48. Tang H, Chen L, Wang Y, et al. The efficacy of music therapy to relieve pain, anxiety, and promote sleep quality, in patients with small cell lung cancer receiving platinum-based chemotherapy. Supportive Care in Cancer. 2021; 29(12): 7299–7306. doi: 10.1007/s00520-021-06152-6
49. Wen Y, Shen X, Shen Y. Improving immersive experiences in virtual natural setting for public health and environmental design: A systematic review and meta-analysis of randomized controlled trials. Mofatteh M, ed. PLOS ONE. 2024; 19(4): e0297986. doi: 10.1371/journal.pone.0297986
50. Phillips R, Fisher BT, Ladas EJ, et al. Use of food restrictions to prevent infections in paediatric patients with cancer and haematopoietic cell transplantation recipients: a systematic review and clinical practice guideline. eClinicalMedicine. 2025; 81: 103093. doi: 10.1016/j.eclinm.2025.103093
51. Önsüz Ü, Can G. Music therapy in various physical and mental conditions and its effects on cancer patients receiving radiotherapy. Psikiyatride Guncel Yaklasimlar. 2025; 17(2): 225–43. doi: 10.3389/fonc.2025.1535851
52. Moghadam MS, Parvizifard A, Foroughi A, et al. An examination of the effectiveness of mindfulness-integrated cognitive behavior therapy on depression, anxiety, stress and sleep quality in Iranian women with breast cancer: a randomized controlled trial. Scientific Reports. 2025; 15(1). doi: 10.1038/s41598-025-85745-1
53. Candan B, Gungor S. Current and evolving concepts in the management of complex regional pain syndrome: A narrative review. Diagnostics. 2025; 15(3): 353. doi: 10.3390/diagnostics15030353
54. Konanc K, Ozturk E. Effects of propolis extract supplementation in breeder and broiler diets and it’s in ovo injection on immune status, blood parameters, vaccine-antibody response and intestinal microflora of broiler chick. Tropical Animal Health and Production. 2025; 57(2). doi: 10.1007/s11250-025-04329-3
55. Boyde C, Berger B, Längler A, et al. Interaction-focused music therapy with cancer-affected children and their significant others: a randomized controlled feasibility study with subsequent intervention (INMUT). Pilot and Feasibility Studies. 2024; 10(1). doi: 10.1186/s40814-024-01490-8
56. Worthen-Chaudhari LC, Crasta JE, Schnell PM, et al. Neurologic dance training and home exercise improve motor-cognitive dual-task function similarly, but through potentially different mechanisms, among breast cancer survivors with chemotherapy-induced neuropathy: Initial results of a randomized, controlled clinical trial. Journal of Alzheimer’s Disease. 2024; 105(4): 1114–1130. doi: 10.1177/13872877241291440
57. Jodie F, Anna K, Ursula W. Effectiveness of music therapy, aromatherapy, and massage therapy on patients in palliative care with end-of-life needs: A systematic review. Journal of Pain and Symptom Management. 2025; 69(1): 102–113. doi: 10.1016/j.jpainsymman.2024.07.024
58. Gillespie K, McConnell T, Roulston A, et al. Music therapy for supporting informal carers of adults with life-threatening illness pre-and post-bereavement: A mixed-methods systematic review. BMC Palliative Care. 2024; 23(1): 55. doi: 10.1186/s12904-024-01364-z
59. Li Y, Ji S, Tao Y, et al. The effect of music therapy on anxiety, depression, pain and sleep quality of lung cancer patients: a systematic review and meta-analysis. Supportive Care in Cancer. 2025; 33(3). doi: 10.1007/s00520-025-09213-2
60. Peng J, Cheng D. The effectiveness of therapeutic artmaking on depression, anxiety, quality of life, and psychological distress in cancer patients on chemotherapy: a systematic review of the literature. Supportive Care in Cancer. 2024; 32(4). doi: 10.1007/s00520-024-08427-0
61. Rodríguez-Rodríguez RC, Noreña-Peña A, Cháfer-Bixquert T, et al. The perception of healthcare professionals, through their own personal experiences, of the use of music therapy in hospitalised children and adolescents. Journal of Pediatric Nursing. 2024; 77: 63–73. doi: 10.1016/j.pedn.2024.02.030
62. Genç Z, Can G, Uyan EK, et al. The effect of breathing exercises on chemotherapy-induced nausea and vomiting in autologous hematopoietic stem cell transplantation patients: A randomized controlled trial. European Journal of Oncology Nursing. 2024; 70: 102618. doi: 10.1016/j.ejon.2024.102618
63. Wang C, Wang Y, Wu F, et al. Fear of progression and resilience as mediators of the association between family function and quality of life among patients with cervical cancer. European Journal of Cancer Care. 2024; 2024(1): 1145993. doi: 10.1155/2024/1145993
64. Devlin K, Kang K, Pantelyat A, et al. Music Therapy and Music-Based Interventions in Neurology. Springer International Publishing; 2023. doi: 10.1007/978-3-031-47092-9
65. Hunt AM, Fachner J, Clark-Vetri R, et al. Neuronal Effects of Listening to Entrainment Music Versus Preferred Music in Patients with Chronic Cancer Pain as Measured via EEG and LORETA Imaging. Frontiers in Psychology. 2021; 12. doi: 10.3389/fpsyg.2021.588788
66. Flores-Gutiérrez EO, Terán-Camarena VA, Alcalá-Lozano R, et al. Music therapy group for women outpatients with major depressive disorder under treatment as usual in a psychiatric institution: non-randomized pilot trial. The Arts in Psychotherapy. 2024; 90: 102171. doi: 10.1016/j.aip.2024.102171
67. de Witte M, Pinho A da S, Stams GJ, et al. Music therapy for stress reduction: a systematic review and meta-analysis. Health Psychology Review. 2020; 16(1): 134–159. doi: 10.1080/17437199.2020.1846580
68. Roveda A, Sydes M, Wood WR. Music-Based Interventions for the Wellbeing of People in Prison: A Systematic Review. Victims & Offenders. 2025; 20(8): 1598–1629. doi: 10.1080/15564886.2025.2470772
69. Arias-Rojas M, Leiserovich N, Castaño M, et al. Experiences of cancer patients in palliative care with advanced care planning: A systematic review and meta-synthesis of qualitative studies. European Journal of Oncology Nursing. 2025; 76: 102868. doi: 10.1016/j.ejon.2025.102868
70. O’Donnell N, Ellis L, Morgan JE, et al. Psychosocial Interventions to Improve Wellbeing in Teenage and Young Adult Post‐Treatment Survivors of Childhood Cancer: A Systematic Review. Psycho-Oncology. 2025; 34(2). doi: 10.1002/pon.70081
71. Fang H, Sun Y, Yu D, et al. Efficacy and results of virtual nursing intervention for cancer patients: A systematic review and meta-analysis. Asia-Pacific Journal of Oncology Nursing. 2024; 11(7): 100515. doi: 10.1016/j.apjon.2024.100515
72. Ibrahim AM, Ali SI, Omar MEHE. Revitalizing Minds: Exploring the Transformative Power of Mindfulness‐Based Nursing Interventions on Depression and Resilience in Oncology Patients—A Quasiexperimental Approach. International Journal of Nursing Practice. 2025; 31(2). doi: 10.1111/ijn.70005
73. Wang JQ, Wang XZ, Wang WX. Acceptance and commitment therapy for enhancing mental health in military personnel: A comprehensive review and meta-analysis. World Journal of Psychiatry. 2025; 15(3). doi: 10.5498/wjp.v15.i3.100959
74. Zhong C, Luo X, Tan M, et al. Digital Health Interventions to Improve Mental Health in Patients with Cancer: Umbrella Review. Journal of Medical Internet Research. 2025; 27: e69621. doi: 10.2196/69621
75. Zeng W, Xu J, Yu J, et al. Effectiveness of virtual reality therapy in the treatment of anxiety disorders in adolescents and adults: a systematic review and meta-analysis of randomized controlled trials. Frontiers in Psychiatry. 2025; 16. doi: 10.3389/fpsyt.2025.1553290
