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Effect of wendan decoction on serum leptin and hypothalamic STAT3 and SOCS3 expression in obese rats

Zhixue Ye

Abstract


Objective To Explore the Possible Mechanism of Wendan Decoction in Treating Obesity .Methods Model of Obesity Rats Induced by High Fat Diet ,Successful Rats were randomly divided into Model Group and Wendan Decoction Group ,Each Group 8 Only , Another 8 Healthy Rats as Normal Group .After successful modeling, rats in each group were fed with basic feed ,while rats in the Wendan Decoction group were given Wendan Decoction 15g/( kg · d ) gavage ,Model group and normal group were gavage with equal amount of distilled water , lasting 6 weeks .Compare the body weight,Lee's Index ,Obesity Rate ,Test Serum Leptin ,Blood Lipid[ Include Total Cholesterol ( TC ) ,Triglyceride ( TG ) ,Low Density Lipoprotein Cholesterol ( LDL-C ) and High Density Lipoprotein Cholesterol ( HDL-C )] and Hypothalamic Tissue Signal Transduction and Transcription Activator 3(STAT3),Cytokine Signal Transduction Inhibitor 3(SOCS3)mRNA mRNA and Protein Expression .Results Compared with normal group, model group rat weight, blood lipid level (except HDL-C, ).hypothalamus, STAT3mRNA, and protein expression increased,SOCS3mRNA and protein expression decreased, (P < 0.01 ).compared with the model group.Wendan decoction group, Lee's index ,body weight , blood lipid level ( except HDL-C )、 hypothalamus ,STAT3mRNA ,and protein expression significantly decreased ,SOCS3mRNA and and protein expression significantly increased ( p < 0.01 ).The obesity rate in the model group was 26.36%, and that in the Wendan decoction group was 1.06%.Conclusion Wendan Decoction has good lipid-lowering effect , It is possible to regulate leptin level,by regulating JAK2/STAT3 signal pathway and thus correct metabolic abnormalities .


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DOI: https://doi.org/10.18282/jim.v0i0.727

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